Evidence map›Paper›PMID 22031659›Full record

Trial reportThe Journal of nutrition2011

Low- and high-dose plant and marine (n-3) fatty acids do not affect plasma inflammatory markers in adults with metabolic syndrome.

Antonella Dewell, Farshad Fani Marvasti, William S Harris, Philip Tsao, Christopher D Gardner

Registry-linked trialOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01129050 (Effects of Plant and Marine Omega-3), which is not on this map. Cited by 54 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 6 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01129050 nacompletednot on this map

Effects of Plant and Marine Omega-3 (w-3) Fatty Acids on Inflammatory Markers In Insulin Resistant Adults

TypeinterventionalSponsorStanford UniversityRan2007 to 2008Enrolled102ConditionsObesity, Hypertriglyceridemia, Insulin Resistance, HypertensionArmsFish Oil, Flaxseed Oil, Placebo
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 6 syntheses or guidelines pooled it, 97 citations in OpenAlex.

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  10. Beneficial Effects of n-3 Fatty Acids on Cardiometabolic and Inflammatory Markers in Type 2 Diabetes Mellitus: A Clinical Trial.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Antonella DewellStanford Prevention Research Center and Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Farshad Fani Marvasti
William S Harris
Philip Tsao
Christopher D Gardner
Stanford University · USStanford Medicine · USUniversity of South Dakota · US

Funding

Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1RR025744 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$22.4M
ALA & EPA/DHA (w-3) Effects On Inflammatory Markers in Insulin Resistant AdultsR21AT003465 · NCCIH · STANFORD UNIVERSITY · PI GARDNER, CHRISTOPHER D · 2006 to 2007
$615k
NCCIH NIH HHS R21 AT003465NCCIH NIH HHS R21AT003465-01NCRR NIH HHS 1UL1 RR025744NCRR NIH HHS UL1 RR025744
6 · The paper itself

Abstract

Chronic inflammation is considered to play a role in the development of cardiovascular disease. Various (n-3) fatty acids (FA) have been reported to have antiinflammatory effects, but there is a lack of consensus in this area, particularly in regard to optimal source(s) and dose(s). This study aimed to determine the effects of high and low doses of (n-3) FA from plant and marine sources on plasma inflammatory marker concentrations. One-hundred adults with metabolic syndrome were randomly assigned to a low or high dose of plant- (2.2 or 6.6 g/d α-linolenic acid) or marine- (1.2 or 3.6 g/d EPA and DHA) derived (n-3) FA or placebo for 8 wk, using a parallel arm design (n = 20/arm). Fasting blood samples collected at 0, 4, and 8 wk were analyzed for concentrations of monocyte chemotactic protein-1 (MCP-1), IL-6, and soluble intercellular adhesion molecule-1 (sICAM-1) and for cardiovascular risk factors. Baseline concentrations across all 5 groups combined were (mean ± SD) 103 ± 32 ng/L for MCP-1, 1.06 ± 0.56 ng/L for IL-6, and 0.197 ± 0.041 ng/L for sICAM-1. There were no significant differences in 8-wk changes in plasma inflammatory marker concentrations among the 5 groups. Plasma TG and blood pressure decreased significantly more and the LDL cholesterol concentration increased more in the high-dose fish oil group compared to the 8-wk changes in some of the other 4 groups (P ≤ 0.04). In conclusion, no beneficial effects were detected for any of the 3 inflammatory markers investigated in response to (n-3) FA in adults with metabolic syndrome regardless of dose or source.

Indexed as

Adultalpha-Linolenic AcidBiomarkersChemokine CCL2Cholesterol, LDLData CollectionDocosahexaenoic AcidsDose-Response Relationship, DrugFatty AcidsFemaleFish OilsHumansInflammationIntercellular Adhesion Molecule-1Interleukin-6Linseed Oilalpha-Linolenic AcidBiomarkersChemokine CCL2Cholesterol, LDLDocosahexaenoic AcidsFatty AcidsFish OilsIntercellular Adhesion Molecule-1Interleukin-6Linseed Oil

Identifiers

PMID22031659
PMCPMC3223874
OpenAlexW2101997203

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.