ArticleProtein science : a publication of the Protein Society2012
A knowledge-based potential highlights unique features of membrane α-helical and β-barrel protein insertion and folding.
Article in Protein science : a publication of the Protein Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Membrane Protein Folding and Biogenesis: Insights from Single-Molecule Force Spectroscopy.Chemical reviews · 2026Review
- Implicit model to capture electrostatic features of membrane environment.PLoS computational biology · 2024Article
- General features of transmembrane beta barrels from a large database.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Modeling intermediates of BamA folding an outer membrane protein.Biophysical journal · 2022Article
- Spatial arrangement of proteins in planar and curved membranes by PPM 3.0.Protein science : a publication of the Protein Society · 2022Article
- Membrane Barrels Are Taller, Fatter, Inside-Out Soluble Barrels.The journal of physical chemistry. B · 2021Article
- Protein Structure Prediction and Design in a Biologically Realistic Implicit Membrane.Biophysical journal · 2020Article
- GeTFEP: A general transfer free energy profile of transmembrane proteins.Protein science : a publication of the Protein Society · 2020Article
- A comprehensive computational study of amino acid interactions in membrane proteins.Scientific reports · 2019Article
- A Membrane Burial Potential with H-Bonds and Applications to Curved Membranes and Fast Simulations.Biophysical journal · 2018Article
- Statistically derived asymmetric membrane potentials from α-helical and β-barrel membrane proteins.Scientific reports · 2018Article
- Outer membrane protein design.Current opinion in structural biology · 2017Review
- Efficient computation of transfer free energies of amino acids in beta-barrel membrane proteins.Bioinformatics (Oxford, England) · 2017Article
- Aromatic Side Chain Water-to-Lipid Transfer Free Energies Show a Depth Dependence across the Membrane Normal.Journal of the American Chemical Society · 2016Article
- Outer Membrane Protein Folding and Topology from a Computational Transfer Free Energy Scale.Journal of the American Chemical Society · 2016Article
- An Integrated Framework Advancing Membrane Protein Modeling and Design.PLoS computational biology · 2015Article
- Computational redesign of the lipid-facing surface of the outer membrane protein OmpA.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Empirical estimation of local dielectric constants: Toward atomistic design of collagen mimetic peptides.Biopolymers · 2015Article
- Life at the border: adaptation of proteins to anisotropic membrane environment.Protein science : a publication of the Protein Society · 2014Review
- Weakly stable regions and protein-protein interactions in beta-barrel membrane proteins.Current pharmaceutical design · 2014Review
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Authors and funding
3 authors.
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Abstract
Outer membrane β-barrel proteins differ from α-helical inner membrane proteins in lipid environment, secondary structure, and the proposed processes of folding and insertion. It is reasonable to expect that outer membrane proteins may contain primary sequence information specific for their folding and insertion behavior. In previous work, a depth-dependent insertion potential, E(z) , was derived for α-helical inner membrane proteins. We have generated an equivalent potential for TM β-barrel proteins. The similarities and differences between these two potentials provide insight into unique aspects of the folding and insertion of β-barrel membrane proteins. This potential can predict orientation within the membrane and identify functional residues involved in intermolecular interactions.
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