ReviewScience translational medicine2011
From DNA to targeted therapeutics: bringing synthetic biology to the clinic.
Review in Science translational medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Multicellular artificial neural network-type architectures demonstrate computational problem solving.Nature chemical biology · 2024Article
- Implementing re-configurable biological computation with distributed multicellular consortia.Nucleic acids research · 2022Article
- Review
- Metabolic engineering generates a transgene-free safety switch for cell therapy.Nature biotechnology · 2020Article
- Pathways to cellular supremacy in biocomputing.Nature communications · 2019Review
- Regulation of T cell proliferation with drug-responsive microRNA switches.Nucleic acids research · 2018Article
- Synthetic Bax-Anti Bcl2 combination module actuated by super artificial hTERT promoter selectively inhibits malignant phenotypes of bladder cancer.Journal of experimental & clinical cancer research : CR · 2016Article
- Spatial and functional heterogeneities shape collective behavior of tumor-immune networks.PLoS computational biology · 2015Article
- Systematic transfer of prokaryotic sensors and circuits to mammalian cells.ACS synthetic biology · 2014Article
- Engineering Escherichia coli for light-activated cytolysis of mammalian cells.ACS synthetic biology · 2014Article
- Synthetic mammalian trigger-controlled bipartite transcription factors.Nucleic acids research · 2013Article
- Regulating synthetic gene networks in 3D materials.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Mapping the environmental fitness landscape of a synthetic gene circuit.PLoS computational biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Synthetic biology aims to make biological engineering more scalable and predictable, lowering the cost and facilitating the translation of synthetic biological systems to practical applications. Increasingly sophisticated, rationally designed synthetic systems that are capable of complex functions pave the way to translational applications, including disease diagnostics and targeted therapeutics. Here, we provide an overview of recent developments in synthetic biology in the context of translational research and discuss challenges at the interface between synthetic biology and clinical medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.