ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2012
Consolidation of remote fear memories involves Corticotropin-Releasing Hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in the dentate gyrus.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- CRH neurons in the dorsal bed nucleus of the stria terminalis (dBNST) mediate contextual fear generalization.Neurobiology of stress · 2026Article
- Role of the hippocampus in systems consolidation of remote fear memory.Experimental & molecular medicine · 2026Review
- Effects of all-trans retinoic acid on glutamate receptor expression and dendritic spine density in the hypothalamus of rats.Frontiers in neuroscience · 2025Article
- Fear learning-induced changes in AMPAR and NMDAR expression in the fear circuit.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Animal models of PTSD: a challenge to be met.Molecular psychiatry · 2019Review
- Clinical Therapeutic Strategy and Neuronal Mechanism Underlying Post-Traumatic Stress Disorder (PTSD).International journal of molecular sciences · 2019Review
- Sound check, stage design and screen plot - how to increase the comparability of fear conditioning and fear extinction experiments.Psychopharmacology · 2019Review
- The CRF Family of Neuropeptides and their Receptors - Mediators of the Central Stress Response.Current molecular pharmacology · 2018Review
- Distribution of corticotropin-releasing factor receptor 1 in the developing mouse forebrain: A novel sex difference revealed in the rostral periventricular hypothalamus.Neuroscience · 2017Article
- Input from the medial geniculate nucleus modulates amygdala encoding of fear memory discrimination.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Converging, Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Allelic variation in CRHR1 predisposes to panic disorder: evidence for biased fear processing.Molecular psychiatry · 2016Article
- Fluoxetine Treatment Rescues Energy Metabolism Pathway Alterations in a Posttraumatic Stress Disorder Mouse Model.Molecular neuropsychiatry · 2016Article
- Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization.Scientific reports · 2016Article
- Stress effects on the hippocampus: a critical review.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Review
- Effects of paroxetine on PTSD-like symptoms in mice.Psychopharmacology · 2015Article
- Neuromodulatory signaling in hippocampus-dependent memory retrieval.Hippocampus · 2015Review
- Schizothorax prenanti corticotropin-releasing hormone (CRH): molecular cloning, tissue expression, and the function of feeding regulation.Fish physiology and biochemistry · 2014Article
- A pilot investigation of the association of genetic polymorphisms regulating corticotrophin-releasing hormone with posttraumatic stress and depressive symptoms in medical-surgical intensive care unit survivors.Journal of critical care · 2014Article
- Superior pattern processing is the essence of the evolved human brain.Frontiers in neuroscience · 2014Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent dreadful memories and hyperarousal constitute prominent psychopathological features of posttraumatic stress disorder (PTSD). Here, we used a contextual fear conditioning paradigm to demonstrate that conditional genetic deletion of corticotropin-releasing hormone (CRH) receptor 1 within the limbic forebrain in mice significantly reduced remote, but not recent, associative and non-associative fear memories. Per os treatment with the selective CRHR1 antagonist DMP696 (3 mg/kg) attenuated consolidation of remote fear memories, without affecting their expression and retention. This could be achieved, if DMP696 was administered for 1 week starting as late as 24 h after foot shock. Furthermore, by combining electrophysiological recordings and western blot analyses, we demonstrate a delayed-onset and long-lasting increase in AMPA receptor (AMPAR) GluR1-mediated signaling in the dentate gyrus (DG) of the dorsal hippocampus 1 month after foot shock. These changes were absent from CRHR1-deficient mice and after DMP696 treatment. Inactivation of hippocampal GluR1-containing AMPARs by antisense oligonucleotides or philantotoxin 433 confirmed the behavioral relevance of AMPA-type glutamatergic neurotransmission in maintaining the high levels of remote fear in shocked mice with intact CRHR1 signaling. We conclude that limbic CRHR1 receptors enhance the consolidation of remote fear memories in the first week after foot shock by increasing the expression of Ca(2+)-permeable GluR1-containing AMPARs in the DG. These findings suggest both receptors as rational targets for the prevention and therapy, respectively, of psychopathology associated with exaggerated fear memories, such as PTSD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.