Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2012
Gray matter volumes in obsessive-compulsive disorder before and after fluoxetine or cognitive-behavior therapy: a randomized clinical trial.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 121 citations in OpenAlex.
- Use of Post-mortem Brain Tissue in Investigations of Obsessive- Compulsive Disorder: A Systematic Review.Current neuropharmacology · 2024Pooled it
- Shape analysis of subcortical structures in obsessive-compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta-analysis by the OCD Brain Imaging Consortium.Brain and behavior · 2022Pooled it
- Defining functional brain networks underlying obsessive-compulsive disorder (OCD) using treatment-induced neuroimaging changes: a systematic review of the literature.Journal of neurology, neurosurgery, and psychiatry · 2021Pooled it
- Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group.The American journal of psychiatry · 2018Pooled it
- Pituitary gland volumes in patients with obsessive-compulsive disorder before and after cognitive-behavioral therapy.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Trial
- The Longitudinal Relationship Between Brain Morphology and Obsessive-Compulsive Symptoms in Children From the General Population.JAACAP open · 2024Article
- Pharmacological and Psychological Treatment Have Common and Specific Effects on Brain Activity in Obsessive-Compulsive Disorder.Depression and anxiety · 2024Article
- A systematic review of structural neuroimaging markers of psychotherapeutic and pharmacological treatment for obsessive-compulsive disorder.Frontiers in psychiatry · 2024Review
- Obsessive-compulsive disorder: Etiology, neuropathology, and cognitive dysfunction.Brain and behavior · 2023Review
- Volumetric MRI Findings in Mild Traumatic Brain Injury (mTBI) and Neuropsychological Outcome.Neuropsychology review · 2023Review
- Article
- Common Gray Matter Reductions in Alcohol Use and Obsessive-Compulsive Disorders: A Meta-analysis.Biological psychiatry global open science · 2022Article
- Structural brain correlates of burnout severity in medical professionals: A voxel-based morphometric study.Neuroscience letters · 2022Article
- Unhealthy mind in a healthy body: A criticism to eliminativism in psychopathology.Frontiers in psychiatry · 2022Article
- Gray Matter Alterations in Pediatric Schizophrenia and Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis of Voxel-Based Morphometry Studies.Frontiers in psychiatry · 2022Article
- Focusing on Comorbidity-A Novel Meta-Analytic Approach and Protocol to Disentangle the Specific Neuroanatomy of Co-occurring Mental Disorders.Frontiers in psychiatry · 2021Article
- Smaller volume of posterior thalamic nuclei in patients with obsessive-compulsive disorder.NeuroImage. Clinical · 2021Article
- Diffusion Tensor Imaging Before and 3 Months After Concentrated Exposure Response Prevention in Obsessive-Compulsive Disorder.Frontiers in psychiatry · 2021Article
- Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters.Translational psychiatry · 2020Article
- Psychiatric neuroimaging research in Brazil: historical overview, current challenges, and future opportunities.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serotonin reuptake inhibitors and cognitive-behavior therapy (CBT) are considered first-line treatments for obsessive-compulsive disorder (OCD). However, little is known about their modulatory effects on regional brain morphology in OCD patients. We sought to document structural brain abnormalities in treatment-naive OCD patients and to determine the effects of pharmacological and cognitive-behavioral treatments on regional brain volumes. Treatment-naive patients with OCD (n=38) underwent structural magnetic resonance imaging scan before and after a 12-week randomized clinical trial with either fluoxetine or group CBT. Matched-healthy controls (n=36) were also scanned at baseline. Voxel-based morphometry was used to compare regional gray matter (GM) volumes of regions of interest (ROIs) placed in the orbitofrontal, anterior cingulate and temporolimbic cortices, striatum, and thalamus. Treatment-naive OCD patients presented smaller GM volume in the left putamen, bilateral medial orbitofrontal, and left anterior cingulate cortices than did controls (p<0.05, corrected for multiple comparisons). After treatment with either fluoxetine or CBT (n=26), GM volume abnormalities in the left putamen were no longer detectable relative to controls. ROI-based within-group comparisons revealed that GM volume in the left putamen significantly increased (p<0.012) in fluoxetine-treated patients (n=13), whereas no significant GM volume changes were observed in CBT-treated patients (n=13). This study supports the involvement of orbitofronto/cingulo-striatal loops in the pathophysiology of OCD and suggests that fluoxetine and CBT may have distinct neurobiological mechanisms of action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.