ArticlePlastic and reconstructive surgery2011
Dose-response effect of human equivalent radiation in the murine mandible: Part II. A biomechanical assessment.
Article in Plastic and reconstructive surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Intraoperative Optimization of Stromal Vascular Fraction for Remediation of Radiated Fracture Repair: Closing the Gap on Clinical Translation of Cell-Based Therapies.Annals of plastic surgery · 2025Article
- Pain hypersensitivity, sensorimotor impairment, and decreased muscle force in a novel rat model of radiation-induced peripheral neuropathy.Journal of the peripheral nervous system : JPNS · 2024Article
- Overcoming Nuclear Winter: The Cutting-edge Science of Bone Healing and Regeneration in Irradiated Fields.Plastic and reconstructive surgery. Global open · 2021Article
- Contemporary biomedical engineering perspective on volitional evolution for human radiotolerance enhancement beyond low-earth orbit.Synthetic biology (Oxford, England) · 2021Review
- Noncultured Minimally Processed Adipose-Derived Stem Cells Improve Radiated Fracture Healing.Annals of plastic surgery · 2020Article
- Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization.NPJ Regenerative medicine · 2019Article
- Radioprotection With Amifostine Enhances Bone Strength and Regeneration and Bony Union in a Rat Model of Mandibular Distraction Osteogenesis.Annals of plastic surgery · 2018Article
- Translational treatment paradigm for managing non-unions secondary to radiation injury utilizing adipose derived stem cells and angiogenic therapy.Head & neck · 2016Article
- Targeting angiogenesis as a therapeutic means to reinforce osteocyte survival and prevent nonunions in the aftermath of radiotherapy.Head & neck · 2015Article
- Raman spectroscopy delineates radiation-induced injury and partial rescue by amifostine in bone: a murine mandibular model.Journal of bone and mineral metabolism · 2015Article
- Prophylactic administration of Amifostine protects vessel thickness in the setting of irradiated bone.Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 2015Article
- Prophylactic amifostine preserves the biomechanical properties of irradiated bone in the murine mandible.Plastic and reconstructive surgery · 2014Article
- New approach for the treatment of osteoradionecrosis with pentoxifylline and tocopherol.Biomaterials research · 2014Review
- Amifostine protects vascularity and improves union in a model of irradiated mandibular fracture healing.Plastic and reconstructive surgery · 2013Article
- Article
- Deferoxamine administration delivers translational optimization of distraction osteogenesis in the irradiated mandible.Plastic and reconstructive surgery · 2013Article
- Dose-response effect of human equivalent radiation in the mandible.The Journal of craniofacial surgery · 2013Article
- Stem cell therapy remediates reconstruction of the craniofacial skeleton after radiation therapy.Stem cells and development · 2013Article
- Deferoxamine restores callus size, mineralization, and mechanical strength in fracture healing after radiotherapy.Plastic and reconstructive surgery · 2013Article
- Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDespite the widespread use of adjuvant irradiation for head and neck cancer, the extent of damage to the underlying bone is not well understood. However, patients can suffer serious clinical consequences, including pathologic fractures, nonunion, and osteoradionecrosis. The authors' specific aim was to objectively quantify the human equivalent radiation dose-response effect of radiation on the biomechanical properties of the murine mandible.
methodsTwelve Sprague-Dawley rats were randomized into three radiation dosage groups--low (5.91 Gy), middle (7 Gy), and high (8.89 Gy)--delivered in five daily fractions. The fractionation regimen was used to approximate 75, 100, and 150 percent, respectively, of the bioequivalent dose humans receive in conventional head and neck cancer treatment. Fifty-six days after irradiation, hemimandibles were loaded to failure in a uniaxial tension at 0.5 mm/second. Load displacement curves were analyzed for yield and breaking load, and values were considered statistically significant at p<0.05.
resultsThe authors' data demonstrated a statistically significant decrease in the yield and breaking load metrics. The authors' reported averages for low, middle, and high radiation dosages were 162, 136, and 69 N, respectively, for yield; and 215, 211, and 141 N, respectively, for breaking load. Both of these quantitative biomechanical properties were diminished in a dose-response pattern.
conclusionsIn this article, the authors report a dose-response effect in the degradation of the biomechanical properties of the mandible after fractionated human equivalent radiation. The authors' findings and model can now be used to formulate therapies aimed at remediating those effects and augmenting bone regeneration and healing after adjuvant radiotherapy in head and neck cancer patients.
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