SynthesisThe Lancet. Infectious diseases2011
Interventions to increase antiretroviral adherence in sub-Saharan Africa: a systematic review of evaluation studies.
Synthesis in The Lancet. Infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03537872 (PROvide MIner-friendly SErvices for Integrated TB/HIV Care in Lesotho Study), which is not on this map. Cited by 143 papers, 20 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PROvide MIner-friendly SErvices for Integrated TB/HIV Care in Lesotho Study (PROMISE Study)
Who cites it
143 citing papers in PubMed, 20 syntheses or guidelines pooled it.
- Antiretroviral Therapy Adherence Interventions in the Era of Universal Test and Treat: A Hybrid Systematic-Narrative Literature Review of Global Evidence.AIDS and behavior · 2026Pooled it
- Implementation strategies to improve HIV care cascade outcomes in low- and middle-income countries: a systematic review from 2014 to 2021.Journal of the International AIDS Society · 2024Pooled it
- Effectiveness of mHealth on Adherence to Antiretroviral Therapy in Patients Living With HIV: Meta-analysis of Randomized Controlled Trials.JMIR mHealth and uHealth · 2023Pooled it
- Interventions to Improve Adherence to Antiretroviral Therapy (ART) in Sub-Saharan Africa: An Updated Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Pooled it
- Strategies for retention of heterosexual men in HIV care in sub-Saharan Africa: A systematic review.PloS one · 2021Pooled it
- Counseling for improving adherence to antiretroviral treatment: a systematic review.AIDS care · 2019Pooled it
- A Systematic Review on Promoting Adherence to Antiretroviral Therapy in HIV-infected Patients Using Mobile Phone Technology.Applied clinical informatics · 2018Pooled it
- Pooled it
- Enhancing Public Health HIV Interventions: A Qualitative Meta-Synthesis and Systematic Review of Studies to Improve Linkage to Care, Adherence, and Retention.EBioMedicine · 2017Pooled it
- Pooled it
- Barriers and facilitators of interventions for improving antiretroviral therapy adherence: a systematic review of global qualitative evidence.Journal of the International AIDS Society · 2016Pooled it
- Retention in care prior to antiretroviral treatment eligibility in sub-Saharan Africa: a systematic review of the literature.BMJ open · 2015Pooled it
- Interventions for Enhancing Adherence to Antiretroviral Therapy (ART): A Systematic Review of High Quality Studies.AIDS patient care and STDs · 2015Pooled it
- Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection: A meta-analysis of randomized controlled trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Pooled it
- Interventions to improve or facilitate linkage to or retention in pre-ART (HIV) care and initiation of ART in low- and middle-income settings--a systematic review.Journal of the International AIDS Society · 2014Pooled it
- Pooled it
- Pooled it
- Telephone delivered interventions for reducing morbidity and mortality in people with HIV infection.The Cochrane database of systematic reviews · 2013Pooled it
- Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection.The Cochrane database of systematic reviews · 2012Pooled it
83 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The success of potent antiretroviral treatment for HIV infection is primarily determined by adherence. We systematically review the evidence of effectiveness of interventions to increase adherence to antiretroviral treatment in sub-Saharan Africa. We identified 27 relevant reports from 26 studies of behavioural, cognitive, biological, structural, and combination interventions done between 2003 and 2010. Despite study diversity and limitations, evidence suggests that treatment supporters, directly observed therapy, mobile-phone text messages, diary cards, and food rations can effectively increase adherence in sub-Saharan Africa. However, some interventions are unlikely to have large or lasting effects, and others are effective only in specific settings. These findings emphasise the need for more research, particularly for randomised controlled trials, to examine the effect of context and specific features of intervention content on effectiveness. Future work should assess intervention targeting and selection of interventions based on behavioural theories relevant to sub-Saharan Africa.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.