ArticleEnvironmental research2012
Fish consumption, low-level mercury, lipids, and inflammatory markers in children.
Article in Environmental research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Assessment of dietary fish consumption in pregnancy: comparing one-, four- and thirty-six-item questionnaires.Public health nutrition · 2014Trial
- Association of weight and dietary habits with high blood mercury levels in Korean adolescents: data from the KoNEHS cycle 4, 2018-2020.Annals of occupational and environmental medicine · 2025Article
- Hair and nail cortisol levels are associated and affected by glucocorticoid use.Psychoneuroendocrinology · 2024Article
- Fish intake and mercury exposure in young children.Environmental research · 2024Article
- Race, cortisol, and subclinical cardiovascular disease in 9- to 11-year-old children.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023Article
- Association of Blood Total Mercury with Dyslipidemia in a sample of U.S. Adolescents: Results from the National Health and Nutrition Examination Survey Database, 2011-2018.Hygiene and environmental health advances · 2023Article
- Physical activity is associated with lower pulsatile stress but not carotid stiffness in children.Journal of human hypertension · 2022Article
- SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner.International journal of molecular sciences · 2020Review
- Guarana improves behavior and inflammatory alterations triggered by methylmercury exposure: an in vivo fruit fly and in vitro neural cells study.Environmental science and pollution research international · 2019Article
- The Putative Role of Environmental Mercury in the Pathogenesis and Pathophysiology of Autism Spectrum Disorders and Subtypes.Molecular neurobiology · 2018Review
- Spatial, Temporal, and Dietary Variables Associated with Elevated Mercury Exposure in Peruvian Riverine Communities Upstream and Downstream of Artisanal and Small-Scale Gold Mining.International journal of environmental research and public health · 2017Article
- Marble industry effluents cause an increased bioaccumulation of heavy metals in Mahaseer (Tor putitora) in Barandu River, district Buner, Pakistan.Environmental science and pollution research international · 2017Article
- Mercury and psychosocial stress exposure interact to predict maternal diurnal cortisol during pregnancy.Environmental health : a global access science source · 2015Article
- Urine cortisol concentration as a biomarker of stress is unrelated to IVF outcomes in women and men.Journal of assisted reproduction and genetics · 2014Article
- Low-level mercury in children: associations with sleep duration and cytokines TNF-α and IL-6.Environmental research · 2014Article
- ERICA: prevalence of fish consumption and its association with cardiovascular risk factors and healthy behavior in Brazilian adolescents.Jornal de pediatriaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
There is considerable evidence that consuming fish has numerous health benefits, including a reduced risk of cardiovascular disease. However, fish is also the primary source of human exposure to mercury (Hg). In a cross-sectional study of 9-11 year old children (N=100), we measured fish consumption, blood lipids, total blood Hg, diurnal salivary cortisol (4 samples collected throughout the day), and performed a proteomic analysis of serum proteins using spectral count shotgun proteomics. Children who consumed fish had a significantly more atheroprotective lipid profile but higher levels of blood Hg relative to children that did not consume fish. Although the levels of blood Hg were very low in these children (M=0.77 μg/L; all but 1 participant had levels below 3.27 μg/L), increasing blood Hg was significantly associated with blunted diurnal cortisol levels. Blood Hg was also significantly associated with acute-phase proteins suggesting systemic inflammation, and several of these proteins were found to significantly reduce the association between Hg and diminished cortisol when included in the model. This study of a pediatric population is the first to document an association between blood Hg, systemic inflammation, and endocrine disruption in humans. Without a better understanding of the long-term consequences of an atheroprotective lipid profile relative to blunted diurnal cortisol and systemic inflammation, a determination of the risk-benefit ratio for fish consumption by children is not possible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.