Why have protein biomarkers not reached the clinic?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

17 citing papers in PubMed.

1. Building a Collaborative Translational Research Platform: Identifying Barriers and Enablers From Basic Research to Primary Healthcare.Cureus · 2025
   Article
2. Biomarkers for Pre-Treatment Risk Stratification of Prostate Cancer Patients: A Systematic Review.Cancers · 2024
   Review
3. An evolutionary learning-based method for identifying a circulating miRNA signature for breast cancer diagnosis prediction.NAR genomics and bioinformatics · 2024
   Article
4. A mini review of leveraging biobanking in the identification of novel biomarkers in neurological disorders: insights from a rapid single-cell sequencing pipeline.Frontiers in neuroscience · 2024
   Review
5. The Potential of Extracellular Matrix- and Integrin Adhesion Complex-Related Molecules for Prostate Cancer Biomarker Discovery.Biomedicines · 2023
   Review
6. Mass spectrometry-based proteomics as an emerging tool in clinical laboratories.Clinical proteomics · 2023
   Review
7. Exact Probability Distribution for the ROC Area under Curve.Cancers · 2023
   Article
8. Genomic and proteomic biomarker landscape in clinical trials.Computational and structural biotechnology journal · 2023
   Article
9. Analysis of Cancer Cell Line Secretomes: A Complementary Source of Disease-Specific Protein Biomarkers.Methods in molecular biology (Clifton, N.J.) · 2023
   Article
10. Lipid Profiling in Cancer Diagnosis with Hand-Held Ambient Mass Spectrometry Probes: Addressing the Late-Stage Performance Concerns.Metabolites · 2021
    Review
11. Discovery of primary prostate cancer biomarkers using cross cancer learning.Scientific reports · 2021
    Article
12. Towards personalized tumor markers.NPJ precision oncology · 2017
    Article
13. Avoiding false discovery in biomarker research.BMC biochemistry · 2016
    Article
14. Biomarkers for Bone Tumors: Discovery from Genomics and Proteomics Studies and Their Challenges.Molecular medicine (Cambridge, Mass.) · 2016
    Article
15. Resolving breast cancer heterogeneity by searching reliable protein cancer biomarkers in the breast fluid secretome.BMC cancer · 2013
    Review
16. The failure of protein cancer biomarkers to reach the clinic: why, and what can be done to address the problem?BMC medicine · 2012
    Article
17. New paradigms in translational science research in cancer biomarkers.Translational research : the journal of laboratory and clinical medicine · 2012
    Review

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.