Evidence map›Paper›PMID 22030221›Full record

Trial reportThe American journal of clinical nutrition2011

Effects of n-3 fatty acids on depressive symptoms and dispositional optimism after myocardial infarction.

Erik J Giltay, Johanna M Geleijnse, Daan Kromhout

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00127452 (Alpha Omega Trial), which is not on this map. Cited by 31 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 14 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00127452 nacompletednot on this map

Alpha Omega Trial: A Randomised, Placebo Controlled, Double Blind Intervention Study of the Effect of Low Doses of Omega-3 Fatty Acids on Cardiovascular Diseases in Patients With a History of Myocardial Infarction

TypeinterventionalSponsorWageningen UniversityRan2002 to 2010Enrolled4,837ConditionsCardiovascular DiseasesArmsmargarine spread
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 14 syntheses or guidelines pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Marine-derived n-3 fatty acids therapy for stroke.The Cochrane database of systematic reviews · 2022
    Pooled it
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  4. Omega-3 fatty acids for depression in adults.The Cochrane database of systematic reviews · 2021
    Pooled it
  5. Pooled it
  6. Pooled it
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  8. Marine-derived n-3 fatty acids therapy for stroke.The Cochrane database of systematic reviews · 2019
    Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
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  13. Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression.The British journal of psychiatry : the journal of mental science · 2016
    Pooled it
  14. Pooled it
  15. Effects of Vitamin DThe Journal of clinical psychiatry · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Erik J GiltayDepartment of Psychiatry, Leiden University Medical Center, Netherlands. e.j.giltay@lumc.nl
Johanna M Geleijnse
Daan Kromhout
Leiden University Medical Center · NL

Funding

Alpha Omega TrialR01HL076200 · NHLBI · WAGENINGEN UNIVERSITY · PI KROMHOUT, DAAN · 2005 to 2008
$1.9M
NHLBI NIH HHS R01-HL076200
6 · The paper itself

Abstract

backgroundIn patients who have experienced a myocardial infarction (MI), n-3 (omega-3) PUFA status is low, whereas the risk of depression is increased.

objectiveThe objective was to assess whether the plant-derived α-linolenic acid (ALA) and the fish fatty acids EPA and DHA would improve affective states.

designIn a secondary analysis of the randomized, double-blind, placebo-controlled Alpha Omega Trial, 4116 of 4837 (85.1%) patients (aged 60-80 y; 79.2% men) who had experienced an MI were included. Margarine spreads were used to deliver 400 mg EPA-DHA/d, 2 g ALA/d, both EPA-DHA and ALA, or a placebo for 40 mo. At 40 mo, the endpoints of depressive symptoms (15-item Geriatric Depression Scale) and dispositional optimism (a 4-item questionnaire and the Life Orientation Test-Revised) were analyzed by using a posttest-only design.

resultsThe 4 randomly assigned groups did not differ in baseline characteristics. ALA supplementation significantly increased plasma cholesteryl ester concentrations of ALA by 69%, and EPA-DHA supplementation increased plasma cholesteryl ester concentrations of EPA and DHA by 61% and 30%, respectively. Depressive symptoms or dispositional optimism did not differ between groups with the use of n-3 fatty acids compared with placebo at the 40-mo follow-up. The standardized mean (±SE) differences in depressive symptoms were as follows: for EPA-DHA plus ALA (n = 1009) compared with placebo (n = 1030), -0.025 ± 0.044 (P = 0.57); for EPA-DHA (n = 1007) compared with placebo, -0.048 ± 0.044 (P = 0.28); and for ALA (n = 1022) compared with placebo, -0.047 ± 0.044 (P = 0.29).

conclusionsIn patients who had experienced an MI, low-dose EPA-DHA supplementation, ALA supplementation, or a combination of both did not affect depressive symptoms and dispositional optimism. These findings are in accord with those from previous trials in individuals without psychopathology or without severe depressive symptoms. This trial was registered at clinicaltrials.gov as NCT00127452.

Indexed as

PersonalityAffectAgedalpha-Linolenic AcidCholesterol EstersDepressionDietary FatsDocosahexaenoic AcidsDouble-Blind MethodEicosapentaenoic AcidFatty Acids, Omega-3FemaleHumansMaleMargarineMiddle Agedalpha-Linolenic AcidCholesterol EstersDietary FatsDocosahexaenoic AcidsEicosapentaenoic AcidFatty Acids, Omega-3Margarine

Identifiers

PMID22030221
PMCPMC3252545
OpenAlexW2150474421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.