ArticleBreast cancer research : BCR2011
Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation.
Article in Breast cancer research : BCR, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Molecular mechanism of bone metastasis in breast cancer.Frontiers in oncology · 2024Review
- miRNA-223 expression in patient-derived eutopic and ectopic endometrial stromal cells and its effect on epithelial-to-mesenchymal transition in endometriosis.Clinics (Sao Paulo, Brazil) · 2022Article
- Comprehensive Review of Molecular Mechanisms and Clinical Features of Invasive Lobular Cancer.The oncologist · 2021Review
- Cadherins in early neural development.Cellular and molecular life sciences : CMLS · 2021Review
- Harmine inhibits breast cancer cell migration and invasion by inducing the degradation of Twist1.PloS one · 2021Article
- Long non-coding RNAs in breast cancer metastasis.Non-coding RNA research · 2020Review
- Glycosphingolipid expression at breast cancer stem cells after novel thieno[2,3-b]pyridine anticancer compound treatment.Scientific reports · 2020Article
- Establishment of primary human breast cancer cell lines using "pulsed hypoxia" method and development of metastatic tumor model in immunodeficient mice.Cancer cell international · 2019Article
- Pancreatic Exocrine Tissue Architecture and Integrity are Maintained by E-cadherin During Postnatal Development.Scientific reports · 2018Article
- Erythropoietin drives breast cancer progression by activation of its receptor EPOR.Oncotarget · 2017Article
- Homeostatic Signaling by Cell-Cell Junctions and Its Dysregulation during Cancer Progression.Journal of clinical medicine · 2016Review
- Lobular breast cancer: molecular basis, mouse and cellular models.Breast cancer research : BCR · 2015Article
- Adhesion in mammary development: novel roles for E-cadherin in individual and collective cell migration.Current topics in developmental biology · 2015Review
- Beyond E-cadherin: roles of other cadherin superfamily members in cancer.Nature reviews. Cancer · 2014Review
- Bex2 is critical for migration and invasion in malignant glioma cells.Journal of molecular neuroscience : MN · 2013Article
- N-cadherin impedes proliferation of the multiple myeloma cancer stem cells.American journal of blood research · 2013Article
- N-cadherin-mediated adhesion and signaling from development to disease: lessons from mice.Progress in molecular biology and translational science · 2013Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionE-cadherin (E-cad; cadherin 1) and N-cadherin (N-cad; cadherin 2) are the most prominent members of the cadherin family of cell adhesion molecules. Although they share many structural and functional features, they are expressed in an almost mutually exclusive manner in vivo.
methodsTo explore functional differences between the two cadherins in vivo, we recently generated a knock-in line in which N-cad is expressed from the E-cad locus. In combination with a conditional gene inactivation approach, we expressed N-cad in the absence of E-cad (referred to as Ncadk.i.) in alveolar epithelial cells of the mammary gland starting in late pregnancy.
resultsWe found that the sole presence of N-cad induces constitutively active fibroblast growth factor (Fgf) signaling and a precocious involution resulting in massive apoptosis of alveolar cells. To block apoptosis, we conditionally deleted one allele of p53 in Ncadk.i. mice and observed a temporal rescue of alveolar morphology and function. However, an accumulation of fibrotic tissue and cysts with increasing age and lactation cycles was observed. This phenotype closely resembled fibrocystic mastopathy (FM), a common disorder in humans, which is thought to precede breast cancer. Concordantly, 55% of Ncadk.i. mice harboring a heterozygous p53 deletion developed malignant and invasive tumors.
conclusionsOur results demonstrate a possible role for N-cad in the formation of fibrosis and cysts in the mammary gland. Moreover, we show that these lesions precede the development of malignant tumors. Thus, we provide a new mouse model to investigate the molecular mechanisms of fibrocystic mastopathy and the transition from benign to malignant tumors.
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