ArticleRadiation research2012
Transcriptional response of ex vivo human skin to ionizing radiation: comparison between low- and high-dose effects.
Article in Radiation research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- A Novel Perfused Full-Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development.Advanced healthcare materials · 2026Article
- High‑dose X‑ray irradiation induces NETosis via the eCIRP/TREM‑1 axis in mouse neutrophils.International journal of molecular medicine · 2025Article
- Histological and Molecular Biological Changes in Canine Skin Following Acute Radiation Therapy-Induced Skin Injury.Animals : an open access journal from MDPI · 2024Article
- Radiation-response in primary fibroblasts of long-term survivors of childhood cancer with and without second primary neoplasms: the KiKme study.Molecular medicine (Cambridge, Mass.) · 2022Article
- Cultured Human Foreskin as a Model System for Evaluating Ionizing Radiation-Induced Skin Injury.International journal of molecular sciences · 2022Article
- An efficient, non-invasive approach forAging · 2021Article
- Comparison of time and dose dependent gene expression and affected pathways in primary human fibroblasts after exposure to ionizing radiation.Molecular medicine (Cambridge, Mass.) · 2020Article
- Cancer immunotherapy: how low-level ionizing radiation can play a key role.Cancer immunology, immunotherapy : CII · 2017Review
- Evaluating biomarkers to model cancer risk post cosmic ray exposure.Life sciences in space research · 2016Review
- RNA Processing and Genome Stability: Cause and Consequence.Molecular cell · 2016Review
- Global Gene Expression Alterations as a Crucial Constituent of Human Cell Response to Low Doses of Ionizing Radiation Exposure.International journal of molecular sciences · 2015Review
- Comparative Analysis of Whole-Genome Gene Expression Changes in Cultured Human Embryonic Stem Cells in Response to Low, Clinical Diagnostic Relevant, and High Doses of Ionizing Radiation Exposure.International journal of molecular sciences · 2015Article
- F1 hybrids of BALB/c and C57BL/6 mouse strains respond differently to low-dose ionizing radiation exposure.Journal of genetics · 2014Article
- High dose ionizing radiation regulates micro RNA and gene expression changes in human peripheral blood mononuclear cells.BMC genomics · 2014Article
- Quantitative Proteomic Profiling of Low-Dose Ionizing Radiation Effects in a Human Skin Model.Proteomes · 2014Article
- Effects of low doses of ionizing radiation exposures on stress-responsive gene expression in human embryonic stem cells.International journal of molecular sciences · 2014Article
- High and low doses of ionizing radiation induce different secretome profiles in a human skin model.PloS one · 2014Article
- Genomic characterization of a three-dimensional skin model following exposure to ionizing radiation.Journal of radiation research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Although human exposure to low-dose ionizing radiation can occur through a variety of sources, including natural, medical, occupational and accidental, the true risks of low-dose ionizing radiation are still poorly understood in humans. Here, the global transcriptional responses of human skin after ex vivo exposure to low (0.05 Gy) and high (5 Gy) doses of X rays and of time in culture (0 Gy) at 0, 2, 8 and 30 h postirradiation were analyzed and compared. Responses to low and high doses differed quantitatively and qualitatively. Differentially expressed genes fell into three groups: (1) unique genes defined as responsive to either 0.05 or 5 Gy but not both and also responsive to time in culture, (2) specific genes defined as responsive to either 0.05 or 5 Gy but not both and not responsive to time in culture, and (3) dose-independent responsive genes. Major differences observed in ex vivo irradiated skin between transcriptional responses to low or high doses were twofold. First, gene expression modulated by 0.05 Gy was transient, while in response to 5 Gy persistence of modified gene expression was observed for a limited number of genes. Second, neither TP53 nor TGFβ target genes were modulated after exposure to an acute low dose, suggesting that the TP53-dependent DNA damage response either was not triggered or was triggered only briefly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.