ArticleBMC neurology2011
Chronic cerebrospinal venous insufficiency in multiple sclerosis: clinical correlates from a multicentre study.
Article in BMC neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Trial
- Flow volume measurement of arterial venous and cerebrospinal fluid in patients with multiple sclerosis.Arquivos de neuro-psiquiatria · 2022Article
- Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer's disease.Journal of neuroinflammation · 2019Article
- The relationship of multiple sclerosis and cerebral developmental venous anomaly with an advantageous role in the multiple sclerosis diagnosis.Iranian journal of neurology · 2017Article
- Centralized and Local Color Doppler Ultrasound Reading Agreement for Diagnosis of the Chronic Cerebrospinal Venous Insufficiency in Patients with Multiple Sclerosis.Current neurovascular research · 2017Article
- An anatomy-based lumped parameter model of cerebrospinal venous circulation: can an extracranial anatomical change impact intracranial hemodynamics?BMC neurology · 2015Article
- Article
- Sources of information and behavioral patterns in online health forums: observational study.Journal of medical Internet research · 2014Observational
- Potential involvement of the extracranial venous system in central nervous system disorders and aging.BMC medicine · 2013Review
- Article
- Article
- Chronic cerebrospinal venous insufficiency: masked multimodal imaging assessment.Multiple sclerosis (Houndmills, Basingstoke, England) · 2013Article
- Chronic cerebrospinal venous insufficiency is not associated with cognitive impairment in multiple sclerosis.BMC medicine · 2013Article
- The role of noninvasive and invasive diagnostic imaging techniques for detection of extra-cranial venous system anomalies and developmental variants.BMC medicine · 2013Review
- Venous hemodynamics in neurological disorders: an analytical review with hydrodynamic analysis.BMC medicine · 2013Review
- CCSVI and MS: no meaning, no fact.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Review
- Chronic cerebrospinal venous insufficiency in multiple sclerosis: a highly prevalent age-dependent phenomenon.BMC neurology · 2013Article
- Chronic cerebrospinal venous insufficiency is not associated with multiple sclerosis and its severity: a blind-verified study.PloS one · 2013Article
- Clinical correlates of chronic cerebrospinal venous insufficiency in multiple sclerosis.BMC neurology · 2012Article
- Internal jugular vein entrapment in a multiple sclerosis patient.Case reports in surgery · 2012Article
Corrections and comments
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Authors and funding
18 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic cerebrospinal venous insufficiency (CCSVI) has recently been reported to be associated with multiple sclerosis (MS). However, its actual prevalence, possible association with specific MS phenotypes, and potential pathophysiological role are debated.
methodWe analysed the clinical data of 710 MS patients attending six centres (five Italian and one Canadian). All were submitted to venous Doppler sonography and diagnosed as having or not having CCSVI according to the criteria of Zamboni et al.
resultsOverall, CCSVI was diagnosed in 86% of the patients, but the frequency varied greatly between the centres. Even greater differences were found when considering singly the five diagnostic criteria proposed by Zamboni et al. Despite these differences, significant associations with clinical data were found, the most striking being age at disease onset (about five years greater in CCSVI-positive patients) and clinical severity (mean EDSS score about one point higher in CCSVI-positive patients). Patients with progressive MS were more likely to have CCSVI than those with relapsing-remitting MS.
conclusionThe methods for diagnosing CCSVI need to be refined, as the between-centre differences, particularly in single criteria, were excessively high. Despite these discrepancies, the strong associations between CCSVI and MS phenotype suggest that the presence of CCSVI may favour a later development of MS in patients with a lower susceptibility to autoimmune diseases and may increase its severity.
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