ArticleJournal of periodontal research2012
Protease inhibitor levels in periodontal health and disease.
Article in Journal of periodontal research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- The Role ofBiomedicines · 2026Review
- Secretory leucocyte protease inhibitor regulates bone metabolism and inflammation in experimental mouse periodontitis.Communications biology · 2025Article
- An Overview of the Etiopathogenic Mechanisms Involved in the Expression of the Oral Microbiota.Clinics and practice · 2025Review
- Synthesis of secretory leukocyte protease inhibitor using cell-free protein synthesis system.Odontology · 2024Article
- Salivary secretory leukocyte protease inhibitor levels in patients with stage 3 grade C periodontitis: a comparative cross-sectional study.Scientific reports · 2022Article
- High Expression and Clinical Significance of Elafin in Colorectal Cancer.Gastroenterology research and practice · 2019Article
- Multi-species oral biofilm promotes reconstructed human gingiva epithelial barrier function.Scientific reports · 2018Article
- Characterization of Antibacterial Cell-Free Supernatant from Oral Care ProbioticMolecules (Basel, Switzerland) · 2018Article
- On site visual detection of Porphyromonas gingivalis related periodontitis by using a magnetic-nanobead based assay for gingipains protease biomarkers.Mikrochimica acta · 2018Article
- Quantification by qPCR of Pathobionts in Chronic Periodontitis: Development of Predictive Models of Disease Severity at Site-Specific Level.Frontiers in microbiology · 2017Article
- Oral infection control to assist infliximab therapy in a Behçet's disease patient with severe eye inflammation in response to dental treatment: a case report.Clinical case reports · 2014Article
- Transcriptional profiling of bone marrow stromal cells in response to Porphyromonas gingivalis secreted products.PloS one · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveOur previous study showed that protease inhibitors were attenuated by the periodontal pathogen Porphyromonas gingivalis in cultured gingival epithelial cells. We hypothesize that fewer protease inhibitors would be present in more advanced periodontal disease sites, where the level of P. gingivalis may be high. The goal of this study was to investigate the relationship between the protease inhibitor [secretory leukocyte protease inhibitor (SLPI), elastase-specific inhibitor (ELAFIN) and squamous cell carcinoma antigen (SCCA)] levels in gingival crevicular fluid and the number of P. gingivalis micro-organisms in subgingival plaque. MATERIAL AND
methodsPlaque samples from subjects without (n = 18) and with moderate to advanced periodontitis (n = 41) were used to quantify P. gingivalis using real-time PCR. Protease inhibitor levels in the gingival crevicular fluid of all the subjects were determined by ELISA.
resultsP. gingivalis was detected in 68.3% of patients with periodontitis, while 16.7% of subjects without periodontitis had a detectable level of P. gingivalis. Patients with periodontitis and P. gingivalis in their plaque exhibited lower SLPI and ELAFIN levels (p < 0.001) compared with control subjects without periodontitis. Secretory leukocyte protease inhibitor was also reduced (p < 0.05) in gingival crevicular fluid of periodontitis patients without a detectable level of P. gingivalis. Periodontitis patients with high vs. low levels of P. gingivalis exhibited reciprocal mean levels of SLPI and ELAFIN concentrations.
conclusionThe reduced concentrations of SLPI and ELAFIN may contribute to the loss of host protective capacity and increase susceptibility to breakdown from chronic infection. The work of this investigation may aid in finding diagnostic and prognostic markers in periodontal health and disease and may also help in finding pharmacological targets directed against periodontal inflammation.
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