Trial reportAddiction (Abingdon, England)2012
Randomized trial of standard methadone treatment compared to initiating methadone without counseling: 12-month findings.
Trial report in Addiction (Abingdon, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00712036 (Entry Into Comprehensive Methadone Treatment Via Interim Maintenance), which is not on this map. Cited by 42 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Entry Into Comprehensive Methadone Treatment Via Interim Maintenance
Who cites it
42 citing papers in PubMed, 7 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Evaluating comparative effect of non-pharmacological interventions adjunctive to opioid agonist therapy for opioid use disorder: A systematic review with network meta-analysis.Addiction (Abingdon, England) · 2026Pooled it
- Interim opioid agonist treatment for opioid addiction: a systematic review.Harm reduction journal · 2022Pooled it
- Pooled it
- Pooled it
- Psychosocial interventions to reduce alcohol consumption in concurrent problem alcohol and illicit drug users.The Cochrane database of systematic reviews · 2018Pooled it
- Supervised dosing with a long-acting opioid medication in the management of opioid dependence.The Cochrane database of systematic reviews · 2017Pooled it
- Retention in medication-assisted treatment for opiate dependence: A systematic review.Journal of addictive diseases · 2016Pooled it
- A trial of implementation facilitation to increase timely admission to methadone treatment.Journal of substance use and addiction treatment · 2024Trial
- Randomized trial of methadone treatment of arrestees: 24-month post-release outcomes.Drug and alcohol dependence · 2021Trial
- Incidence of future arrests in adults involved in the criminal justice system with opioid use disorder receiving extended release naltrexone compared to treatment as usual.Drug and alcohol dependence · 2019Trial
- Interim buprenorphine treatment during delays to comprehensive treatment: Changes in psychiatric symptoms.Experimental and clinical psychopharmacology · 2018Trial
- A pilot feasibility randomised controlled trial of an adjunct brief social network intervention in opiate substitution treatment services.BMC psychiatry · 2018Trial
- Treatment outcomes among a cohort of African American buprenorphine patients: Follow-up at 12 months.The American journal of drug and alcohol abuse · 2018Trial
- Patient-centered methadone treatment: a randomized clinical trial.Addiction (Abingdon, England) · 2017Trial
- Interim methadone and patient navigation in jail: Rationale and design of a randomized clinical trial.Contemporary clinical trials · 2016Trial
- Interim versus standard methadone treatment: a benefit-cost analysis.Journal of substance abuse treatment · 2014Trial
- Methadone induction in primary care for opioid dependence: a pragmatic randomized trial (ANRS Methaville).PloS one · 2014Trial
- Retention in methadone and buprenorphine treatment among African Americans.Journal of substance abuse treatment · 2013Trial
- A randomized trial of intensive outpatient (IOP) vs. standard outpatient (OP) buprenorphine treatment for African Americans.Drug and alcohol dependence · 2013Trial
- Improvements in outcomes in methadone patients on probation/parole regardless of counseling early in treatment.Journal of addiction medicineTrial
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
aimsThis study aimed to determine the relative effectiveness of 12 months of interim methadone (IM; supervised methadone with emergency counseling only for the first 4 months of treatment), standard methadone treatment (SM; with routine counseling) and restored methadone treatment (RM: routine counseling with smaller case-loads).
designA randomized controlled trial was conducted comparing IM, SM and RM treatment. IM lasted for 4 months, after which participants were transferred to SM.
settingThe study was conducted in two methadone treatment programs in Baltimore, MD, USA.
participantsThe study included 230 adult methadone patients newly admitted through waiting-lists. MEASUREMENTS: We administered the Addiction Severity Index and a supplemental questionnaire at baseline, 4 and 12 months post- baseline. Measurements included retention in treatment, self-reported days of heroin and cocaine use, criminal behavior and arrests and urine tests for heroin and cocaine metabolites.
findingsAt 12 months, on an intent-to-treat basis, there were no significant differences in retention in treatment among the IM, SM and RM groups (60.6%, 54.8% and 37.0%, respectively). Positive urine tests for the three groups declined significantly from baseline (Ps < 0.001 and 0.003, for heroin and cocaine metabolites, respectively) but there were no significant group x time interactions for these measures. At least one arrest was reported by 30.6% of the sample during the year, but there were no significant between-group effects.
conclusionsLimited availability of drug counseling services should not be a barrier to providing supervised methadone to adults dependent on heroin--at least for the first 4 months of treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.