Evidence map›Paper›PMID 22029362›Full record

ArticleJournal of biomedical optics2011

Tumor characterization in small animals using magnetic resonance-guided dynamic contrast enhanced diffuse optical tomography.

Yuting Lin, Dave Thayer, Orhan Nalcioglu, Gultekin Gulsen

Open access · bronzeAbstract read
In one paragraph

Article in Journal of biomedical optics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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  9. Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Yuting LinUniversity of California, Irvine, Tu and Yuen Center for Functional Onco-Imaging, Irvine, California 92697, USA. yutingl@uci.edu
Dave Thayer
Orhan Nalcioglu
Gultekin Gulsen
University of California, Irvine · USPusan National University · KR

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Joel E Milam · 1994 to 2026
$57.9M
Developing DOSI Technology for Monitoring Response To Breast Cancer ChemotherapyR01CA142989 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY J · 2010 to 2017
$4.1M
Development of A Multi-Modality System for Onco-ImagingR33CA120175 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI GULSEN, GULTEKIN · 2008 to 2010
$1.5M
Tomographic Molecular Imaging for Breast CancerR01EB008716 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI GULSEN, GULTEKIN · 2008 to 2011
$1.3M
Combined MRI and Optical Imaging to Improved Breast Cancer DiagnosisR21CA121568 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI SU, MIN-YING L. · 2007 to 2008
$580k
Development of A Multi-Modality System for Onco-ImagingR21CA120175 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI GULSEN, GULTEKIN · 2007 to 2007
$225k
NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA142989NCI NIH HHS R01CA142989NCI NIH HHS R21/33 CA120175NCI NIH HHS R21 CA120175NCI NIH HHS R21 CA121568NCI NIH HHS R33 CA120175NIBIB NIH HHS R01 EB008716NIBIB NIH HHS R01EB008716
6 · The paper itself

Abstract

We present a magnetic resonance (MR)-guided near-infrared dynamic contrast enhanced diffuse optical tomography (DCE-DOT) system for characterization of tumors using an optical contrast agent (ICG) and a MR contrast agent [Gd-diethylenetriaminepentaacetic acid (DTPA)] in a rat model. Both ICG and Gd-DTPA are injected and monitored simultaneously using a combined MRI-DOT system, resulting in accurate co-registration between two imaging modalities. Fisher rats bearing R3230 breast tumor are imaged using this hybrid system. For the first time, enhancement kinetics of the exogenous contrast ICG is recovered from the DCE-DOT data using MR anatomical a priori information. As tumors grow, they undergo necrosis and the tissue transforms from viable to necrotic. The results show that the physiological changes between viable and necrotic tissue can be differentiated more accurately based on the ICG enhancement kinetics when MR anatomical information is utilized.

Indexed as

AnimalsContrast MediaFemaleGadolinium DTPAIndocyanine GreenMagnetic Resonance ImagingMammary Neoplasms, ExperimentalNecrosisOptical PhenomenaRatsRats, Inbred F344Tomography, OpticalContrast MediaGadolinium DTPAIndocyanine Green

Identifiers

PMID22029362
PMCPMC3221711
OpenAlexW2095001775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.