ArticleJournal of biomedical optics2011
Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography.
Article in Journal of biomedical optics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Optical coherence tomography to identify upper airway obstruction sites in an apneic patient.Biophotonics discovery · 2024Article
- Graph-based rotational nonuniformity correction for localized compliance measurement in the human nasopharynx.Biomedical optics express · 2021Article
- Localized compliance measurement of the airway wall using anatomic optical coherence elastography.Optics express · 2019Article
- Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review.Otolaryngology (Sunnyvale, Calif.) · 2019Article
- Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway.Journal of biomedical optics · 2018Article
- Multi-modal anatomical Optical Coherence Tomography and CT forProceedings of SPIE--the International Society for Optical Engineering · 2017Article
- Optical coherence elastography for tissue characterization: a review.Journal of biophotonics · 2015Review
- Mechanical analysis of arterial plaques in native geometry with OCT wall motion analysis.Journal of biomechanics · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Optical coherence tomography (OCT) is a nondestructive imaging technique offering high temporal and spatial resolution, which makes it a natural choice for assessing tissue mechanical properties. We have developed methods to mechanically analyze the compliance of the rabbit trachea in vivo using tissue deformations induced by tidal breathing, offering a unique tool to assess the behavior of the airways during their normal function. Four-hundred images were acquired during tidal breathing with a custom-built endoscopic OCT system. The surface of the tissue was extracted from a set of these images via image processing algorithms, filtered with a bandpass filter set at respiration frequency to remove cardiac and probe motion, and compared to ventilatory pressure to calculate wall compliance. These algorithms were tested on elastic phantoms to establish reliability and reproducibility. The mean tracheal wall compliance (in five animals) was 1.3±0.3×10(-5) (mm Pa)(-1). Unlike previous work evaluating airway mechanics, this new method is applicable in vivo, noncontact, and loads the trachea in a physiological manner. The technique may have applications in assessing airway mechanics in diseases such as asthma that are characterized by significant airway remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.