ArticleIndian journal of endocrinology and metabolism2011
Management of diabetes insipidus in children.
Article in Indian journal of endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 59 citations in OpenAlex.
- A Prospective Study of the Incidence and Characteristics of Post-Obstructive Diuresis Following Pyeloplasty for Unilateral Pelvi-Ureteric Junction Obstruction.Urology research & practice · 2026Article
- A Case of Misdiagnosed Pediatric Congenital Nephrogenic Diabetes Insipidus due to AQP2 Variants.Case reports in pediatrics · 2026Article
- Diagnostic Pitfalls of a Newborn with Congenital Nephrogenic Diabetes InsipidusJournal of clinical research in pediatric endocrinology · 2025Article
- Etiology of combined pituitary hormone deficiency: GNAO1 as a novel candidate gene.Endocrine connections · 2024Article
- Management of Acute Kidney Injury in Extremely Low Birth Weight Infants.Frontiers in pediatrics · 2022Review
- Nephrogenic diabetes insipidus in children (Review).Experimental and therapeutic medicine · 2021Review
- Type 3 antenatal Bartter syndrome presenting with mild polyuria.BMJ case reports · 2021Article
- Hypertensive urgency in nephrogenic diabetes insipidus with concomitant Hinman syndrome.BMJ case reports · 2019Article
- Transient endocrinologic problems in the newborn period.Turk pediatri arsivi · 2019Review
- Activation of AQP2 water channels without vasopressin: therapeutic strategies for congenital nephrogenic diabetes insipidus.Clinical and experimental nephrology · 2018Review
- Brain Death in Children: Incidence, Donation Rates, and the Occurrence of Central Diabetes Insipidus.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2018Article
- Diabetes insipidus in pediatric patients.Indian journal of pediatrics · 2014Article
- Endocrinopathies in survivors of childhood neoplasia.Frontiers in pediatrics · 2014Review
- Necrotizing infundibuloneurohypophysitis: case report and literature review.Endocrine pathology · 2012Review
- CONGENITAL NEPHROGENIC DIABETES INSIPIDUS IN A PRETERM INFANT: CASE PRESENTATION.Acta endocrinologica (Bucharest, Romania : 2005)Article
- Primary Polydipsia in a Toddler: A Rare Case.Journal of investigative medicine high impact case reportsArticle
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes Insipidus (DI) is a heterogeneous clinical syndrome of disturbance in water balance, characterized by polyuria (urine output > 4 ml/kg/hr), polydypsia (water intake > 2 L/m(2)/d) and failure to thrive. In children, Nephrogenic DI (NDI) is more common than Central DI (CDI), and is often acquired. The signs and symptoms vary with etiology, age at presentation and mode of onset. Neonates and infants with NDI are severely affected and difficult to treat. Diagnosis is based on the presence of high plasma osmolality and low urinary osmolality with significant water diuresis. Water deprivation test with vasopressin challenge, though has limitations, is done to differentiate NDI and CDI and diagnose their partial forms. Measurement of urinary aquaporin 2 and serum copeptin levels are being studied and show promising diagnostic potential. Magnetic Resonance Imaging (MRI) pituitary helps in the etiological diagnosis of CDI, absence of posterior pituitary bright signal being the pathognomic sign. If pituitary stalk thickening of < 2 mm is present, these children need to be monitored for evolving lesion. Neonates and young infants are better managed with fluids alone. Older children with CDI are treated with desmopressin. The oral form is safe, highly effective, with more flexibility of dosing and has largely replaced the intranasal form. In NDI besides treatment of the underlying cause, use of high calorie low solute diet and drugs to ameliorate water excretion (thiazide, amelioride, indomethacin) are useful. Children with NDI however well treated, remain short and have mental retardation on follow up.
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