ArticleEplasty2011
Use of platelet rich plasma gel on wound healing: a systematic review and meta-analysis.
Article in Eplasty, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 75 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Platelets Rich Plasma as a Therapeutic Tool in Chronic Non Healing Diabetic Foot Ulcers
The Effect of Platelet Rich Plasma on Pain at Skin Graft Donor Sites
Who cites it
75 citing papers in PubMed, 5 syntheses or guidelines pooled it, 209 citations in OpenAlex.
- The Effectiveness, Safety and Cost-Effectiveness of Platelet-Rich Plasma and Platelet-Rich Fibrin in the Treatment of Venous Leg Ulcers: A Systematic Review and Meta-Analysis.International wound journal · 2026Pooled it
- Efficacy and safety of allogeneic platelet-rich plasma in chronic wound treatment: a meta-analysis of randomized controlled trials.Scientific reports · 2024Pooled it
- Clinical Studies on Platelet-Rich Plasma Therapy for Chronic Cutaneous Ulcers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Advances in wound care · 2022Pooled it
- Adjuvant Biological Therapies in Chronic Leg Ulcers.International journal of molecular sciences · 2017Pooled it
- SIMTI recommendations on blood components for non-transfusional use.Blood transfusion = Trasfusione del sangue · 2013Guideline
- Aurix Gel Is an Effective Intervention for Chronic Diabetic Foot Ulcers: A Pragmatic Randomized Controlled Trial.Advances in skin & wound care · 2019Trial
- REGENERATION OF CHRONIC WOUNDS WITH ALLOGENEIC PLATELET GELActa clinica Croatica · 2018Trial
- Treatment of chronic non-healing ulcers using autologous platelet rich plasma: a case series.Journal of biomedical science · 2017Trial
- Platelet-rich plasma in the management of diabetic foot ulcers (Review).Biomedical reports · 2026Review
- Efficacy of Platelet-Rich Plasma and Polyvinyl Alcohol Wound Dressing in Open Wound Healing: First Results from an Experimental Rat Model.European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes · 2026Article
- Regenerative effects of PRP-impregnated collagen-gelatin sponge in a full-thickness skin defect model.Regenerative therapy · 2025Article
- The Effect of Platelet Rich Plasma on Wound Healing in Pressure Ulcer Patient Grade III and IV.International wound journal · 2025Article
- Article
- Novel platelet-rich plasma/ hyaluronic acid lyophilized formulations for wound healing applications.Frontiers in bioengineering and biotechnology · 2025Article
- Platelet-rich plasma treatment for chronic wounds: A case report and literature review.World journal of clinical cases · 2024Article
- The Effect of Platelet-Rich Plasma on the Healing of Nasal Mucosa After Surgery of the Nose: A Randomized Clinical Trial.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Novel Biological-Based Strategy for Synthesis of Green Nanochitosan and Copper-Chitosan Nanocomposites: Promising Antibacterial and Hematological Agents.Nanomaterials (Basel, Switzerland) · 2024Article
- Platelet-rich plasma therapy for postoperative esophageal fistula in a pediatric patient.Journal of surgical case reports · 2024Article
- Do Intraoperative Platelet-Rich Plasma Injections Influence the Final Appearance of Vertical Scars after Breast Reduction? Spectrophotometric Analysis.Journal of clinical medicine · 2024Article
- Advances with Platelet-Rich Plasma for Bone Healing.Biologics : targets & therapy · 2024Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAutologous platelet rich plasma is an advanced wound therapy used in hard-to-heal acute and chronic wounds. To better understand the use and clinical outcomes of the therapy, a systematic review of the published literature in cutaneous wounds was performed.
methodsElectronic and hand searches for randomized controlled trials and comparative group studies using platelet rich plasma therapy in cutaneous wounds and published over the last 10 years was conducted. Eligible studies compared the treatment to standard care or other interventions. All citations were screened and eligible studies were assessed for validity, quality, and bias using accepted scoring methods. The primary outcomes were effect of platelet rich plasma and control wound care on wound healing and related healing measurements. Secondary outcomes related to healing such as infection, pain, exudate, adverse events, and quality of life were also considered. The meta-analysis utilized appropriate statistical methods to determine the overall treatment effect on chronic and acute wound healing and infection.
resultsThe search terms resulted in 8577 citations and after removing duplicates and screening for protocol eligibility, a total of 24 papers were used. The meta-analysis of chronic wound studies revealed platelet rich plasma therapy is significantly favored for complete healing. The meta-analysis of acute wounds with primary closure studies demonstrated that presence of infection was reduced in platelet rich plasma treated wounds.
conclusionsThis systematic review and meta-analysis of platelet rich plasma therapy in cutaneous wounds showed complete and partial wound healing was improved compared to control wound care.
Identifiers
22028946PMC3174862W161266538What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.