ArticlePloS one2011
Rhesus macaques (Macaca mulatta) are natural hosts of specific Staphylococcus aureus lineages.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Antimicrobial Resistance Profiles, Virulence Determinants, and Biofilm Formation in Enterococci Isolated from Rhesus Macaques (Animals : an open access journal from MDPI · 2023Article
- Staphylococcus nasal colonization in three species of non-human primates.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Characterization and epidemiology of antimicrobial resistance patterns ofFrontiers in veterinary science · 2023Article
- Sequence Analysis of NovelInternational journal of molecular sciences · 2022Article
- Hematology and Culture Assessment of Cranially Implanted Rhesus Macaques (Comparative medicine · 2021Article
- Safety and Immunogenicity of a 4-Component Toxoid-BasedFrontiers in immunology · 2021Article
- Evaluation of Topical Lysostaphin as a Novel Treatment for Instrumented Rhesus Macaques (Comparative medicine · 2020Article
- Review
- Carriage of Methicillin-resistantComparative medicine · 2019Article
- Article
- Association of Primate Veterinarians Guidelines For Mrsa Infections in Nonhuman Primates in Biomedical Research.Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Evaluation of the Pig-Tailed Macaque (Macaca nemestrina) as a Model of Human Staphylococcus aureus Nasal Carriage.Infection and immunity · 2018Article
- An experimental Staphylococcus aureus carriage and decolonization model in rhesus macaques (Macaca mulatta).PloS one · 2018Article
- The commensal lifestyle of Staphylococcus aureus and its interactions with the nasal microbiota.Nature reviews. Microbiology · 2017Review
- A Simple Way to Eradicate Methicillin-ResistantComparative medicine · 2017Article
- Evaluation of non-invasive biological samples to monitor Staphylococcus aureus colonization in great apes and lemurs.PloS one · 2013Article
- Characterization of Staphylococcus aureus isolates from faecal samples of the Straw-Coloured Fruit Bat (Eidolon helvum) in Obafemi Awolowo University (OAU), Nigeria.BMC microbiology · 2012Article
- Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis.The EMBO journal · 2012Article
- Article
- Staphylococcus aureus Infecting and Colonizing Experimental Animals, Macaques, in a Research Animal Facility.Microbial drug resistance (Larchmont, N.Y.)Observational
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently, there is no animal model known that mimics natural nasal colonization by Staphylococcus aureus in humans. We investigated whether rhesus macaques are natural nasal carriers of S. aureus. Nasal swabs were taken from 731 macaques. S. aureus isolates were typed by pulsed-field gel electrophoresis (PFGE), spa repeat sequencing and multi-locus sequence typing (MLST), and compared with human strains. Furthermore, the isolates were characterized by several PCRs. Thirty-nine percent of 731 macaques were positive for S. aureus. In general, the macaque S. aureus isolates differed from human strains as they formed separate PFGE clusters, 50% of the isolates were untypeable by agr genotyping, 17 new spa types were identified, which all belonged to new sequence types (STs). Furthermore, 66% of macaque isolates were negative for all superantigen genes. To determine S. aureus nasal colonization, three nasal swabs from 48 duo-housed macaques were taken during a 5 month period. In addition, sera were analyzed for immunoglobulin G and A levels directed against 40 staphylococcal proteins using a bead-based flow cytometry technique. Nineteen percent of the animals were negative for S. aureus, and 17% were three times positive. S. aureus strains were easily exchanged between macaques. The antibody response was less pronounced in macaques compared to humans, and nasal carrier status was not associated with differences in serum anti-staphylococcal antibody levels. In conclusion, rhesus macaques are natural hosts of S. aureus, carrying host-specific lineages. Our data indicate that rhesus macaques are useful as an autologous model for studying S. aureus nasal colonization and infection prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.