ArticlePloS one2011
The expression and function of fatty acid transport protein-2 and -4 in the murine placenta.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 67 citations in OpenAlex.
- SLC27, solute carrier 27 family, a long-chain fatty acid membrane transporters, in human cancers.Frontiers in cell and developmental biology · 2026Review
- The role of candidate transport proteins in β-cell long-chain fatty acid uptake: Where are we now?Diabetic medicine : a journal of the British Diabetic Association · 2023Review
- Ectopic Lipid Accumulation Correlates with Cellular Stress in Rabbit Blastocysts from Diabetic Mothers.International journal of molecular sciences · 2023Article
- The lipase cofactor CGI58 controls placental lipolysis.JCI insight · 2023Article
- Muscle Lipid Oxidation Is Not Affected by Obstructive Sleep Apnea in Diabetes and Healthy Subjects.International journal of molecular sciences · 2023Article
- Assessing hypoxic damage to placental trophoblasts by measuring membrane viscosity of extracellular vesicles.Placenta · 2022Article
- Placental Function and the Development of Fetal Overgrowth and Fetal Growth Restriction.Obstetrics and gynecology clinics of North America · 2021Review
- Uteroplacental Insufficiency with Hypoxia Upregulates Placental PPARγ-KMT5A Axis in the Rat.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Complex, coordinated and highly regulated changes in placental signaling and nutrient transport capacity in IUGR.Biochimica et biophysica acta. Molecular basis of disease · 2020Review
- The effect of high glucose on lipid metabolism in the human placenta.Scientific reports · 2019Article
- PLIN2 Is Essential for Trophoblastic Lipid Droplet Accumulation and Cell Survival During Hypoxia.Endocrinology · 2018Article
- Fatty acid transporting proteins: Roles in brain development, aging, and stroke.Prostaglandins, leukotrienes, and essential fatty acids · 2018Review
- The Effect of Hypoxia and Metformin on Fatty Acid Uptake, Storage, and Oxidation in L6 Differentiated Myotubes.Frontiers in endocrinology · 2018Article
- [Expression of FABP7 in mouse placenta tissue and human trophoblast HTR-8/Svneo cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Article
- Exercise rescues obese mothers' insulin sensitivity, placental hypoxia and male offspring insulin sensitivity.Scientific reports · 2017Article
- Maternal obesity modulates intracellular lipid turnover in the human term placenta.International journal of obesity (2005) · 2017Article
- Transplacental Nutrient Transport Mechanisms of Intrauterine Growth Restriction in Rodent Models and Humans.Frontiers in physiology · 2017Review
- Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity.Placenta · 2016Article
- Article
- Real-Time Tracking of BODIPY-C12 Long-Chain Fatty Acid in Human Term Placenta Reveals Unique Lipid Dynamics in Cytotrophoblast Cells.PloS one · 2016Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe uptake and trans-placental trafficking of fatty acids from the maternal blood into the fetal circulation are essential for embryonic development, and involve several families of proteins. Fatty acid transport proteins (FATPs) uniquely transport fatty acids into cells. We surmised that placental FATPs are germane for fetal growth, and are regulated during hypoxic stress, which is associated with reduced fat supply to the fetus. METHODOLOGY/PRINCIPAL
findingsUsing cultured primary term human trophoblasts we found that FATP2, FATP4 and FATP6 were highly expressed in trophoblasts. Hypoxia enhanced the expression of trophoblastic FATP2 and reduced the expression of FATP4, with no change in FATP6. We also found that Fatp2 and Fatp4 are expressed in the mouse amnion and placenta, respectively. Mice deficient in Fatp2 or Fatp4 did not deviate from normal Mendelian distribution, with both embryos and placentas exhibiting normal weight and morphology, triglyceride content, and expression of genes related to fatty acid mobilization. CONCLUSIONS/SIGNIFICANCE: We conclude that even though hypoxia regulates the expression of FATP2 and FATP4 in human trophoblasts, mouse Fatp2 and Fatp4 are not essential for intrauterine fetal growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.