ReviewClinical & developmental immunology2012
Immune aspects and myometrial actions of progesterone and CRH in labor.
Review in Clinical & developmental immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Perinatal vulnerability: its impact on oral and craniofacial hard tissue development.Frontiers in physiology · 2026Review
- Application of Carbon Nanomaterials to Enhancing Tumor Immunotherapy: Current Advances and Prospects.International journal of nanomedicine · 2024Review
- Crucial role of corticotropin-releasing hormone, corticotropin-releasing hormone -binding protein, mir-200c, and mir-181a in preterm delivery: A case-control study.International journal of reproductive biomedicine · 2023Article
- Role of Transcription Factors in the Management of Preterm Birth: Impact on Future Treatment Strategies.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- The CRHR1/CREB/REST signaling cascade regulates mammalian embryonic neural stem cell properties.EMBO reports · 2023Article
- Article
- Effects of Hormone Therapy and Flavonoids Capable on Reversal of Menopausal Immune Senescence.Nutrients · 2021Review
- Accurate prediction of birth implementing a statistical model through the determination of steroid hormones in saliva.Scientific reports · 2021Article
- Retracted Article: Structural characterization ofRSC advances · 2019Article
- Progesterone-Related Immune Modulation of Pregnancy and Labor.Frontiers in endocrinology · 2019Review
- Application effect of single balloon catheters in labor induction of pregnant women in late-term pregnancy and their influences on stress and inflammatory responses.Experimental and therapeutic medicine · 2018Article
- Stress and the HPA Axis: Balancing Homeostasis and Fertility.International journal of molecular sciences · 2017Review
- Bridging progestogens in pregnancy and pregnancy prevention.Endocrine connections · 2015Review
- Immunomodulatory effects of sex hormones: requirements for pregnancy and relevance in melanoma.Mayo Clinic proceedings · 2014Review
- Menstrual cycle influence on cognitive function and emotion processing-from a reproductive perspective.Frontiers in neuroscience · 2014Review
- Updates in reproduction coming from the endocannabinoid system.International journal of endocrinology · 2014Review
- Key role of CRF in the skin stress response system.Endocrine reviews · 2013Review
- Monocyte function in the fetus and the preterm neonate: immaturity combined with functional impairment.Mediators of inflammation · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progesterone and corticotropin-releasing hormone (CRH) have a critical role in pregnancy and labor, as changes related to these hormones are crucial for the transition from myometrial quiescence to contractility. The mechanisms related to their effect differ between humans and other species, thus, despite extensive research, many questions remain to be answered regarding their mediation in human labor. Immune responses to progesterone and CRH are important for labor. Progesterone acts as an immunomodulator which controls many immune actions during pregnancy, and its withdrawal releases the inhibitory action on inflammatory pathways. In humans, a "functional" progesterone withdrawal occurs with onset of labor through changes in progesterone metabolism, progesterone receptors, and other molecules that either facilitate or antagonize progesterone function. Placental CRH acts on the fetal pituitary-adrenal axis to stimulate adrenal production of androgens and cortisol and also acts directly on myometrial cells via its receptors. CRH also affects inflammatory signals and vice versa. Interactions between progesterone and CRH additionally occur during labor. We describe the role of these two hormones in human myometrium and their interactions with the immune system during labor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.