ArticleFrontiers in neuroscience2011
Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain.
Article in Frontiers in neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Gene co-expression changes underlying the functional connectomic alterations in Alzheimer's disease.BMC medical genomics · 2022Pooled it
- GTsurvival: A Hybrid GCN-Neural Decision Tree Model for Restricted Mean Survival Time Prediction with Complex Censored Data.Entropy (Basel, Switzerland) · 2025Article
- Fractional Anisotropy Alterations in Key White Matter Pathways Associated with Cognitive Performance Assessed by MoCA.Neurology international · 2025Article
- Single-Cell Transcriptomic Profiling Reveals Regional Differences in the Prefrontal and Entorhinal Cortex of Alzheimer's Disease Brain.International journal of molecular sciences · 2025Article
- Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI.Scientific data · 2025Article
- A Site-Wise Reliability Analysis of the ABCD Diffusion Fractional Anisotropy and Cortical Thickness: Impact of Scanner Platforms.Human brain mapping · 2024Article
- Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease.Human brain mapping · 2023Article
- Inter- and intra-individual variation in brain structural-cognition relationships in aging.NeuroImage · 2022Article
- The additive impact of cardio-metabolic disorders and psychiatric illnesses on accelerated brain aging.Human brain mapping · 2022Article
- Translating ENIGMA schizophrenia findings using the regional vulnerability index: Association with cognition, symptoms, and disease trajectory.Human brain mapping · 2022Article
- Sex Chromosome Dosage Effects on White Matter Structure in the Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Stage-dependent involvement of ADAM10 and its significance in epileptic seizures.Journal of cellular and molecular medicine · 2019Review
- Associations and Heritability of Auditory Encoding, Gray Matter, and Attention in Schizophrenia.Schizophrenia bulletin · 2019Article
- Linking Cortical and Connectional Pathology in Schizophrenia.Schizophrenia bulletin · 2019Article
- Genomic kinship construction to enhance genetic analyses in the human connectome project data.Human brain mapping · 2019Article
- Genetic influences on neonatal cortical thickness and surface area.Human brain mapping · 2018Article
- Altered white-matter integrity in unaffected siblings of probands with autism spectrum disorders.Human brain mapping · 2017Article
- Potassium channel gene associations with joint processing speed and white matter impairments in schizophrenia.Genes, brain, and behavior · 2017Article
- Heritability and genetic correlation between the cerebral cortex and associated white matter connections.Human brain mapping · 2016Article
- Heritability of the limbic networks.Social cognitive and affective neuroscience · 2016Article
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Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
Abstract
objectivesThe thickness of the brain's cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated by common biological mechanisms. We employed four types of genetic analyses to localize individual genes acting pleiotropically upon these phenotypes.
methodsWhole-brain and regional GM thickness and FA values were measured from high-resolution anatomical and diffusion tensor MR images collected from 712, Mexican American participants (438 females, age = 47.9 ± 13.2 years) recruited from 73 (9.7 ± 9.3 individuals/family) large families. The significance of the correlation between two traits was estimated using a bivariate genetic correlation analysis. Localization of chromosomal regions that jointly influenced both traits was performed using whole-genome quantitative trait loci (QTL) analysis. Gene localization was performed using SNP genotyping on Illumina 1M chip and correlation with leukocyte-based gene-expression analyses. The gene-expressions were measured using the Illumina BeadChip. These data were available for 371 subjects.
resultsSignificant genetic correlation was observed among GM thickness and FA values. Significant logarithm of odds (LOD ≥ 3.0) QTLs were localized within chromosome 15q22-23. More detailed localization reported no significant association (p < 5·10(-5)) for 1565 SNPs located within the QTLs. Post hoc analysis indicated that 40% of the potentially significant (p ≤ 10(-3)) SNPs were localized to the related orphan receptor alpha (RORA) and NARG2 genes. A potentially significant association was observed for the rs2456930 polymorphism reported as a significant GWAS finding in Alzheimer's disease neuroimaging initiative subjects. The expression levels for RORA and ADAM10 genes were significantly (p < 0.05) correlated with both FA and GM thickness. NARG2 expressions were significantly correlated with GM thickness (p < 0.05) but failed to show a significant correlation (p = 0.09) with FA. DISCUSSION: This study identified a novel, significant QTL at 15q22-23. SNP correlation with gene-expression analyses indicated that RORA, NARG2, and ADAM10 jointly influence GM thickness and WM-FA values.
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