Evidence map›Paper›PMID 22028449›Full record

ReviewEndocrinology2011

Minireview: Recent advances in extranuclear steroid receptor actions.

Stephen R Hammes, Ellis R Levin

Open access · bronzeAbstract readReview
In one paragraph

Review in Endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 145 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Androgen-induced epigenetic modulations in the ovary.The Journal of endocrinology · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Stephen R HammesDepartment of Medicine, University of Rochester, Rochester, New York 14642, USA. stephen_hammes@urmc.rochester.edu
Ellis R Levin
University of California, Irvine · USUniversity of Rochester · US

Funding

Non-genomic actions of estrogen in breast cancerR01CA100366 · NCI · SOUTHERN CALIFORNIA INST FOR RES/EDUC · PI LEVIN, ELLIS R · 2004 to 2014
$2.3M
NCI NIH HHS R01 CA100366
6 · The paper itself

Abstract

The participation of extranuclear steroid receptor signaling in organ physiology and the impact for pathobiology has increasingly been demonstrated. Important functions of membrane estrogen receptors in the cardiovascular system demonstrate new mechanisms of rapid steroid signaling to gene regulation, preventing cardiovascular disease and maintaining healthy arterial function. In cancer cells, kinase signaling initiated by extranuclear estrogen, progesterone, and androgen receptors modulates transcriptional events in the nucleus, which in turn regulate proliferation, migration, and invasion. Important mediators of cross talk between cytoplasmic and nuclear steroid receptor signaling are the proline-, glutamic acid-, and leucine-rich protein-1 and paxillin proteins, both of which modulate membrane and nuclear receptor pool signaling to promote a variety of cell biological functions.

Indexed as

HumansNeoplasmsReceptors, Cytoplasmic and NuclearReceptors, EstrogenReceptors, SteroidSignal TransductionReceptors, Cytoplasmic and NuclearReceptors, EstrogenReceptors, Steroid

Identifiers

PMID22028449
PMCPMC3858720
OpenAlexW1971841422

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.