ArticleCardiovascular research2012
Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells.
Article in Cardiovascular research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Genome ofInternational journal of molecular sciences · 2022Article
- Injury Characteristics and von Willebrand Factor for the Prediction of Acute Respiratory Distress Syndrome in Patients With Burn Injury: Development and Internal Validation.Annals of surgery · 2019Article
- The Dynamics of the Skin's Immune System.International journal of molecular sciences · 2019Review
- Examining the contribution of surrounding intact skin during cutaneous healing.Journal of anatomy · 2019Article
- The zebrafish miR-125c is induced under hypoxic stressOncotarget · 2017Article
- Endothelial progenitor cells and burn injury - exploring the relationship.Burns & trauma · 2016Review
- Molecular mechanisms of ischemic preconditioning in the kidney.American journal of physiology. Renal physiology · 2015Review
- Kidney injury is independent of endothelial HIF-1α.Journal of molecular medicine (Berlin, Germany) · 2015Article
- microRNA and Wound Healing.Advances in experimental medicine and biology · 2015Article
- Loss of endothelial-ARNT in adult mice contributes to dampened circulating proangiogenic cells and delayed wound healing.Vascular medicine (London, England) · 2014Article
- Hypoxic signaling during tissue repair and regenerative medicine.International journal of molecular sciences · 2014Review
- Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury.The Journal of clinical investigation · 2014Article
- Spatial vascular volume fraction imaging for quantitative assessment of angiogenesis.Molecular imaging and biology · 2014Article
- Combination of HIF-1α gene transfection and HIF-1-activated bone marrow-derived angiogenic cell infusion improves burn wound healing in aged mice.Gene therapy · 2013Article
- Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus.Journal of molecular medicine (Berlin, Germany) · 2013Article
- Endometriosis, a disease of the macrophage.Frontiers in immunology · 2013Article
- Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
aimsHypoxia-inducible factor 1 (HIF-1) is a heterodimer composed of HIF-1α and HIF-1β subunits. HIF-1 is known to promote tissue vascularization by activating the transcription of genes encoding angiogenic factors, which bind to receptors on endothelial cells (ECs) and bone marrow-derived angiogenic cells (BMDACs). In this study, we analysed whether HIF-1 activity in the responding ECs and BMDACs is also required for cutaneous vascularization during burn wound healing. METHODS AND
resultsWe generated mice with floxed alleles at the Hif1a or Arnt locus encoding HIF-1α and HIF-1β, respectively. Expression of Cre recombinase was driven by the Tie2 gene promoter, which is expressed in ECs and bone marrow cells. Tie2Cre(+) and Tie2Cre(-) mice were subjected to burn wounds of reproducible diameter and depth. Deficiency of HIF-1α or HIF-1β in Tie2-lineage cells resulted in delayed wound closure, reduced vascularization, decreased cutaneous blood flow, impaired BMDAC mobilization, and decreased BMDAC homing to burn wounds.
conclusionHIF-1 activity in Tie2-lineage cells is required for the mobilization and homing of BMDACs to cutaneous burn wounds and for the vascularization of burn wound tissue.
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