ReviewDisease models & mechanisms2012
Exploring the elephant: histopathology in high-throughput phenotyping of mutant mice.
Review in Disease models & mechanisms, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Restoring comparative expertise to improve translation of animal models.Disease models & mechanisms · 2026Review
- Identifying genetic determinants of outer retinal function in mice using a large-scale gene-targeted screen.PLoS genetics · 2025Article
- [Centers for experimental animal pathology still occupy a small but valuable niche in translational medicine-time for change?]Pathologie (Heidelberg, Germany) · 2024Review
- Review
- Predicting human disease mutations and identifying drug targets from mouse gene knockout phenotyping campaigns.Disease models & mechanisms · 2019Review
- Training mouse pathologists: 16Lab animal · 2018Article
- Training mouse pathologists: 15 years of workshops on the pathology of mouse models of human disease.Lab animal · 2017Article
- Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.PloS one · 2017Article
- High-Throughput, Multi-Image Cryohistology of Mineralized Tissues.Journal of visualized experiments : JoVE · 2016Article
- Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- Show and tell: disclosure and data sharing in experimental pathology.Disease models & mechanisms · 2016Review
- The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents.Veterinary pathology · 2016Article
- Excavating the Genome: Large-Scale Mutagenesis Screening for the Discovery of New Mouse Models.The journal of investigative dermatology. Symposium proceedings · 2015Review
- Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.Disease models & mechanisms · 2014Article
- Integrating pathology into human disease modelling--how to eat the elephant.Disease models & mechanisms · 2014Article
- High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.Bone research · 2014Article
- The mouse pathology ontology, MPATH; structure and applications.Journal of biomedical semantics · 2013Article
- New insights into behaviour using mouse ENU mutagenesis.Human molecular genetics · 2012Review
- The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Towards an encyclopaedia of mammalian gene function: the International Mouse Phenotyping Consortium.Disease models & mechanisms · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Recent advances in gene knockout techniques and the in vivo analysis of mutant mice, together with the advent of large-scale projects for systematic mouse mutagenesis and genome-wide phenotyping, have allowed the creation of platforms for the most complete and systematic analysis of gene function ever undertaken in a vertebrate. The development of high-throughput phenotyping pipelines for these and other large-scale projects allows investigators to search and integrate large amounts of directly comparable phenotype data from many mutants, on a genomic scale, to help develop and test new hypotheses about the origins of disease and the normal functions of genes in the organism. Histopathology has a venerable history in the understanding of the pathobiology of human and animal disease, and presents complementary advantages and challenges to in vivo phenotyping. In this review, we present evidence for the unique contribution that histopathology can make to a large-scale phenotyping effort, using examples from past and current programmes at Lexicon Pharmaceuticals and The Jackson Laboratory, and critically assess the role of histopathology analysis in high-throughput phenotyping pipelines.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.