ArticlePrenatal diagnosis2011
Noninvasive prenatal diagnosis: pregnant women's interest and expected uptake.
Article in Prenatal diagnosis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 132 citations in OpenAlex.
- Genetic counseling and testing for Asian Americans: a systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2021Pooled it
- Effects of an animated educational video on knowledge of cell-free DNA screening among Thai pregnant women: a randomized control trial.BMC pregnancy and childbirth · 2023Trial
- Comparing the Introduction and Implementation of Noninvasive Prenatal Testing (NIPT) in Japan, the Netherlands, and the United States: An Integrative Review.Prenatal diagnosis · 2025Review
- Aspiring toward equitable benefits from genomic advances to individuals of ancestrally diverse backgrounds.American journal of human genetics · 2024Review
- Article
- Providing recurrence risk counselling for parents after diagnosis of a serious genetic condition caused by an apparently de novo mutation in their child: a qualitative investigation of the PREGCARE strategy with UK clinical genetics practitioners.Journal of medical genetics · 2023Article
- Non-Invasive Prenatal Testing (NIPT): Reliability, Challenges, and Future Directions.Diagnostics (Basel, Switzerland) · 2023Review
- Patient perspectives on noninvasive prenatal testing among black women in the United States: a scoping review.BMC pregnancy and childbirth · 2023Article
- Article
- Women's Attitudes Toward Invasive and Noninvasive Testing When Facing a High Risk of Fetal Down Syndrome.JAMA network open · 2019Article
- Evaluation of preferences of women and healthcare professionals in Singapore for implementation of noninvasive prenatal testing for Down syndrome.Singapore medical journal · 2017Article
- A Framework for Describing the Influence of Service Organisation and Delivery on Participation in Fetal Anomaly Screening in England.Journal of pregnancy · 2017Article
- Spanish- and English-Speaking Pregnant Women's Views on cfDNA and Other Prenatal Screening: Practical and Ethical Reflections.Journal of genetic counseling · 2016Article
- Uptake, outcomes, and costs of implementing non-invasive prenatal testing for Down's syndrome into NHS maternity care: prospective cohort study in eight diverse maternity units.BMJ (Clinical research ed.) · 2016Article
- "This lifetime commitment": Public conceptions of disability and noninvasive prenatal genetic screening.American journal of medical genetics. Part A · 2016Article
- Non-invasive Prenatal Diagnosis for BRCA Mutations - a Qualitative Pilot Study of Health Professionals' Views.Journal of genetic counseling · 2016Article
- Factors associated with utilization of maternal serum screening for Down syndrome in mainland China: a cross-sectional study.BMC health services research · 2016Article
- Non-invasive prenatal testing for fetal chromosome abnormalities: review of clinical and ethical issues.The application of clinical genetics · 2016Review
- Positive Attitudes towards Non-Invasive Prenatal Testing (NIPT) in a Swedish Cohort of 1,003 Pregnant Women.PloS one · 2016Article
- Online direct-to-consumer messages about non-invasive prenatal genetic testing.Reproductive biomedicine & society online · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo investigate pregnant women's level of future interest in noninvasive prenatal diagnosis (NIPD) and what factors might affect expected uptake of this testing.
methodWritten questionnaires were administered to women in their third trimester.
resultsOne hundred fourteen women returned the questionnaire (80.9% response rate). Of these, 71.9% reported interest in NIPD, 22.7% were ambivalent, and 5.4% were uninterested. Safety of the fetus was the single most important factor in 75% of women's decisions. Factors associated with increased interest in NIPD included: older age (p = 0.036), higher education (p = 0.013), Caucasian or Asian ethnicity (p = 0.011), and higher likelihood to terminate an affected pregnancy (p = 0.002). Nearly 20% of women reported that they would do whatever their doctor recommended regarding NIPD, and 94.4% of women wished to meet with a genetic counselor at some point to discuss NIPD.
conclusionThe majority of pregnant women report hypothetical interest in NIPD, primarily because of increased safety for the fetus, although a significant minority are uninterested or ambivalent. Discussions with healthcare providers regarding NIPD, and their recommendations, are likely to be an important factor in women's decisions about this testing. As such, adequate discussion of the implications of prenatal diagnostic testing will be critical.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.