ArticleThe Journal of biological chemistry2011
Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Trial
- GIP Receptor Antagonists in the Pharmacotherapy of Obesity: Physiologic, Genetic, and Clinical Rationale.Diabetes · 2025Review
- The MEC-2E isoform with a large C-terminal completely rescues the touch sensation defect of C. elegans.Scientific reports · 2025Article
- Physiology and clinical applications of GIP.Endocrine journal · 2025Review
- The Premise of the Paradox: Examining the Evidence That Motivated GIPR Agonist and Antagonist Drug Development Programs.Journal of clinical medicine · 2025Review
- Which is the real nature of glucose-dependent insulinotropic peptide?: Endogenous vs pharmacological.Journal of diabetes investigation · 2025Article
- Pathogenesis of type 2 diabetes in Japan and East Asian populations: Basic and clinical explorations.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- Incretin hormones and pharmacomimetics rapidly inhibit AgRP neuron activity to suppress appetite.bioRxiv : the preprint server for biology · 2024Article
- Infection-elicited microbiota promotes host adaptation to nutrient restriction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Hypertension Related to Obesity: Pathogenesis, Characteristics and Factors for Control.International journal of molecular sciences · 2022Review
- Glucose-dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet-fed mice.British journal of pharmacology · 2022Article
- GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue.Diabetes · 2022Article
- Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms.Molecular metabolism · 2021Review
- A compendium of G-protein-coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure.Clinical science (London, England : 1979) · 2020Review
- Pharmacological antagonism of the incretin system protects against diet-induced obesity.Molecular metabolism · 2020Article
- Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake.Cell metabolism · 2019Article
- Physiological roles of the GIP receptor in murine brown adipose tissue.Molecular metabolism · 2019Article
- Increased Body Weight and Fat Mass After Subchronic GIP Receptor Antagonist, but Not GLP-2 Receptor Antagonist, Administration in Rats.Frontiers in endocrinology · 2019Article
- Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes.Endocrine reviews · 2018Review
- Searching for the physiological role of glucose-dependent insulinotropic polypeptide.Journal of diabetes investigation · 2016Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The glucose-dependent insulinotropic polypeptide receptor (GIPr) has been implicated in high fat diet-induced obesity and is proposed as an anti-obesity target despite an uncertainty regarding the mechanism of action. To independently investigate the contribution of the insulinotropic effects and the direct effects on adipose tissue, we generated transgenic mice with targeted expression of the human GIPr to white adipose tissue or beta-cells, respectively. These mice were then cross-bred with the GIPr knock-out strain. The central findings of the study are that mice with GIPr expression targeted to adipose tissue have a similar high fat diet -induced body weight gain as control mice, significantly greater than the weight gain in mice with a general ablation of the receptor. Surprisingly, this difference was due to an increase in total lean body mass rather than a gain in total fat mass that was similar between the groups. In contrast, glucose-dependent insulinotropic polypeptide-mediated insulin secretion does not seem to be important for regulation of body weight after high fat feeding. The study supports a role of the adipocyte GIPr in nutrient-dependent regulation of body weight and lean mass, but it does not support a direct and independent role for the adipocyte or beta-cell GIPr in promoting adipogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.