ReviewJournal of pediatric gastroenterology and nutrition2012
Brain-gut axis: from basic understanding to treatment of IBS and related disorders.
Review in Journal of pediatric gastroenterology and nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Psychosocial Interventions for the Treatment of Functional Abdominal Pain Disorders in Children: A Systematic Review and Meta-analysis.JAMA pediatrics · 2022Pooled it
- Altered Sigmoid Mucosal Innervation and Mast Cell Proximity to Sensory Nerve Fibers Are Associated With Symptom Severity in Patients With Irritable Bowel Syndrome.Neurogastroenterology and motility · 2025Article
- The "brain-gut" mechanism of postherpetic neuralgia: a mini-review.Frontiers in neurology · 2025Review
- Differences in Prevalence and Psychosocial Characteristics of Irritable Bowel Syndrome According to Rome III and Rome IV Criteria in Medical and Nursing Students.Journal of neurogastroenterology and motility · 2024Article
- Hemorrhoidal disease and its genetic association with depression, bipolar disorder, anxiety disorders, and schizophrenia: a bidirectional mendelian randomization study.Human genomics · 2024Article
- ZO-1 and IL-1RAP Phosphorylation: Potential Role in Mediated Brain-Gut Axis Dysregulation in Irritable Bowel Syndrome-like Stressed Mice.International journal of medical sciences · 2024Article
- Review
- Association between Serum Vitamin D and Irritable Bowel Syndrome Symptoms in a Sample of Adults.Nutrients · 2022Article
- High Rates of Non-Response Across Treatment Attempts in Chronic Irritable Bowel Syndrome: Results From a Follow-Up Study in Tertiary Care.Frontiers in psychiatry · 2019Article
- Brain-Gut Axis: Clinical Implications.Gastroenterology clinics of North America · 2018Review
- Hirschsprung disease - integrating basic science and clinical medicine to improve outcomes.Nature reviews. Gastroenterology & hepatology · 2018Review
- Migraine in young females with irritable bowel syndrome: still a challenge.Neuropsychiatric disease and treatment · 2018Article
- A NMDA-receptor calcium influx assay sensitive to stimulation by glutamate and glycine/D-serine.Scientific reports · 2017Article
- Neuroendocrine Dysregulation in Irritable Bowel Syndrome Patients: A Pilot Study.Journal of neurogastroenterology and motility · 2017Article
- Maternal Weaning Modulates Emotional Behavior and Regulates the Gut-Brain Axis.Scientific reports · 2016Article
- Pathogenesis, Experimental Models and Contemporary Pharmacotherapy of Irritable Bowel Syndrome: Story About the Brain-Gut Axis.Current neuropharmacology · 2016Review
- Aspects of the non-pharmacological treatment of irritable bowel syndrome.World journal of gastroenterology · 2015Review
- The role of AST-120 and protein-bound uremic toxins in irritable bowel syndrome: a therapeutic perspective.Therapeutic advances in gastroenterology · 2015Review
- Observational
- Low-FODMAP Diet for Irritable Bowel Syndrome: Is It Ready for Prime Time?Digestive diseases and sciences · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The present review describes advances in understanding the mechanisms and provide an update of present and promising therapy directed at the gut or the brain in the treatment of irritable bowel syndrome (IBS). The diagnosis of IBS typically is based on identification of symptoms, such as the Rome III criteria for IBS in adults and children. The criteria are similar in children and adults. The focus of the present review is the bowel dysfunction associated with IBS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.