ArticleEnvironmental health perspectives2012
Renal function after reduction in cadmium exposure: an 8-year follow-up of residents in cadmium-polluted areas.
Article in Environmental health perspectives, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 114 citations in OpenAlex.
- Article
- Metallothionein and Other Factors Influencing Cadmium-Induced Kidney Dysfunction: Review and Commentary.Biomolecules · 2025Review
- The pathogenesis of albuminuria in cadmium nephropathy.Current research in toxicology · 2024Article
- Iron Administration Partially Ameliorates Cadmium-Induced Oxidative Damage in the Liver and Kidney of Rats.Journal of toxicology · 2024Article
- Bioaccumulation of Lead, Cadmium, and Arsenic in a Mining Area and Its Associated Health Effects.Toxics · 2023Article
- Cadmium: A Focus on the Brown Crab (Toxics · 2022Review
- Nephrotoxic Biomarkers with Specific Indications for Metallic Pollutants: Implications for Environmental Health.Biomarker insights · 2022Review
- The Aging Kidney-As Influenced by Heavy Metal Exposure and Selenium Supplementation.Biomolecules · 2021Review
- Elevated cadmium and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in residents living near electroplating industries.Environmental science and pollution research international · 2021Article
- Dose-response evaluation of urinary cadmium and kidney injury biomarkers in Chinese residents and dietary limit standards.Environmental health : a global access science source · 2021Article
- Article
- Adverse Impact of Heavy Metals on Bone Cells and Bone Metabolism Dependently and Independently through Anemia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Article
- The association between cumulative cadmium intake and osteoporosis and risk of fracture in a Chinese population.Journal of exposure science & environmental epidemiology · 2019Article
- Associations between blood cadmium concentration and kidney function in the U.S. population: Impact of sex, diabetes and hypertension.Environmental research · 2019Article
- An interventional study of rice for reducing cadmium exposure in a Chinese industrial town.Environment international · 2019Article
- Risk factors for chronic kidney disease of non-traditional causes: a systematic review.Revista panamericana de salud publica = Pan American journal of public health · 2019Review
- Hepato-Renal protective Effects of Egyptian Purslane Extract against Experimental Cadmium Toxicity in Rats with Special Emphasis on the Functional and Histopathological Changes.Toxicology reports · 2019Article
- Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study.International journal of obesity (2005) · 2018Article
- Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveLong-term exposure to cadmium (Cd) causes renal dysfunction, but the change in renal function with exposure is unknown. We assessed the evolution of Cd-induced renal effects after a reduction in dietary exposure to Cd in rice.
methodsFour hundred twelve residents in previously Cd-polluted and nonpolluted areas were examined twice, in 1998 and in 2006. Changes in blood Cd, urinary Cd, and kidney function [N-acetyl-β-d-glucosaminidase (NAG), β2-microglobulin, and albumin in urine] were measured.
resultsIn the most polluted area, mean blood Cd was 8.9 μg/L and 3.3 μg/L in 1998 and in 2006, respectively, and urinary Cd was 11.6 and 9.0 μg/g creatinine. Urinary albumin in 1998 increased with urinary Cd, but no such exposure-response relation appeared for 2006 albumin versus urinary Cd 1998, indicating recovery. Other biomarkers of kidney function were also elevated in 1998. Partial recovery was observed for NAG among women and was suggested for β2-microglobulin among young individuals. The probability of having β2-microglobulin levels above the 95th percentile in 2006 was high in those with elevated β2-microglobulin in 1998 [odds ratio (OR) = 24.8; 95% confidence interval (CI): 11.2, 55.3] compared with albumin (OR = 3.0; 95% CI: 1.2, 7.5) and NAG (OR = 2.6; 95% CI: 1.6, 4.4).
conclusionsResults suggest that a Cd-mediated increase in urinary albumin excretion is reversible upon substantial reduction of exposure. For markers of tubular effects, we observed a tendency toward improvement but not complete recovery. Data from repeated observations suggest that β2-microglobulin may be more informative than NAG as an indicator for an individual's future tubular function.
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