ArticleJournal of diabetes science and technology2011
Injection force of reusable insulin pens: Novopen 4, Lilly Luxura, Berlipen, and ClikSTAR.
Article in Journal of diabetes science and technology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- A review of reusable insulin pens and features of TouStar-a new reusable pen with a dedicated cartridge.Diabetology & metabolic syndrome · 2021Review
- Half-Unit Insulin Pens: Disease Management in Patients With Diabetes Who Are Sensitive to Insulin.Journal of diabetes science and technology · 2017Review
- Functional Evaluation of the Reusable JuniorSTAR® Half-Unit Insulin Pen.Journal of diabetes science and technology · 2015Article
- Dialing torque preferences of people with diabetes when using insulin pens: a pilot study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2015Article
- A comparison of glide force characteristics between 2 prefilled insulin lispro pens.Journal of diabetes science and technology · 2015Article
- Dose accuracy and injection force of different insulin glargine pens.Journal of diabetes science and technology · 2013Article
- Dose accuracy of the ClikSTAR, NovoPen 4, and Luxura insulin pens: results of laboratory and field studies.Journal of diabetes science and technology · 2011Article
- Analysis: linking laboratory data to human factors and inclusion of persons with disabilities in diabetes technology research.Journal of diabetes science and technology · 2011Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsulin pen devices are used by approximately half of insulin users worldwide. The injection force of insulin pens is a key element in their design. This study aimed to demonstrate that the sanofi-aventis reusable ClikSTAR® (CS) pen has an improved injection force over existing insulin pens.
methodsThe injection force of four reusable insulin pens--Novopen® 4 (NP4; Novo Nordisk), Luxura® (LL; Eli Lilly and Co.), Berlipen® (BP; Haselmeier GmbH), and CS (sanofi-aventis)--was tested in a laboratory setting. Injection force was tested using two methods: six dispense rates between 6 and 24.66 U/s (constant volume flow rate) and constant button speeds of 4 and 8 mm/s.
resultsThe CS required a lower mean injection force versus NP4, LL, and BP at both doses and all dispense rates. Mean injection force was 45%, 126%, and 60% higher for NP4, LL, and BP versus CS, respectively (p < .05 for each of the comparisons), for a flow rate of 6 U/s at 60 U dose. Mean injection force in all pens increased with the dispense rate, but the injection force remained significantly lower for CS versus all other pens (p < .05). The injection force for CS was significantly lower for 60 U at 10 and 17.03 U/s than for 80 U.
conclusionsThe study demonstrated that CS pens require a lower injection force at a wide range of different injection speeds than other reusable insulin pens. This is an important benefit for patients with diabetes, especially those with limited dexterity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.