ArticleBMC infectious diseases2011
Molecular typing of Mycobacterium tuberculosis isolates circulating in Jiangsu province, China.
Article in BMC infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- First Insight into the Molecular Epidemiology ofBioMed research international · 2017Trial
- A First Insight into the Genetic Diversity and Drug Susceptibility Pattern ofBioMed research international · 2016Trial
- Risk factors for diagnosis and treatment delay among patients with multidrug-resistant tuberculosis in Hunan Province, China.BMC infectious diseases · 2024Article
- Genomic characteristics ofFrontiers in microbiology · 2023Article
- Genetic Diversity and Drug Susceptibility Profiles of Multidrug-Resistant Tuberculosis Strains in Southeast China.Infection and drug resistance · 2021Article
- Genotypes of Mycobacterium tuberculosis isolates circulating in Shaanxi Province, China.PloS one · 2020Article
- Genetic diversity and drug resistance of Mycobacterium tuberculosis in Yunnan, China.Journal of clinical laboratory analysis · 2019Article
- Prevalence, risk and genetic characteristics of drug-resistant tuberculosis in a tertiary care tuberculosis hospital in China.Infection and drug resistance · 2019Article
- Genetic diversity of drug resistant Mycobacterium Tuberculosis in local area of Southwest China: a retrospective study.BMC infectious diseases · 2018Article
- Role of MIRU-VNTR and spoligotyping in assessing the genetic diversity of Mycobacterium tuberculosis in Henan Province, China.BMC infectious diseases · 2018Article
- Diagnostic Performance of the GenoType MTBDRChinese medical journal · 2017Article
- Molecular & genetic characteristics ofThe Indian journal of medical research · 2017Article
- Article
- Genotypic Diversity ofBioMed research international · 2017Article
- Genotyping and drug-resistance epidemiology ofInternational journal of clinical and experimental pathology · 2017Article
- Molecular Typing Characteristic and Drug Susceptibility Analysis of Mycobacterium tuberculosis Isolates from Zigong, China.BioMed research international · 2016Article
- Article
- Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Hunan, China.Antimicrobial agents and chemotherapy · 2014Article
- Development of a hierarchical variable-number tandem repeat typing scheme for Mycobacterium tuberculosis in China.PloS one · 2014Article
- Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolates from China.Antimicrobial agents and chemotherapy · 2014Article
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11 authors.
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Abstract
backgroundGlobally, China is the second place with high burden of tuberculosis (TB). To explore the characteristics of the pathogens of Mycobacterium tuberculosis (MTB) circulating in this area is helpful for understanding and controlling the spread of the strains. Recent developments in molecular biology have allowed prompt identification and tracking specific strains of MTB spreading through the population.
methodsSpacer-oligonucleotide typing (spoligotyping) and mycobacterial interspersed repetitive units variable number tandem repeat (MIRU-VNTR) were performed in combination to yield specific genetic profiles of 260 MTB strains isolated from 30 counties of Jiangsu province in China between June and July 2010. The spoligotyping results were in comparison to the world Spoligotyping Database of Institute Pasteur de Guadeloupe (SpolDB4). Drug susceptibility test (DST) was performed on all strains by proportion method on Lowenstein-Jensen (LJ) culture media.
resultsBased on the spoligotyping method, 246 strains displayed known patterns and 14 were absent in the database. Predominant spoligotypes belonged to the Beijing family (80.4%). By using the 24-loci VNTR typing scheme, 224 different patterns were identified, including 20 clusters and 204 unique patterns. The largest clade comprised 195 strains belonging to the Beijing family. The combination of spoligotyping and 24-loci MIRU-VNTR demonstrated maximal discriminatory power. Furthermore, we observed a significant association between Beijing family strains and drug-resistant phenotypes. The Beijing family strains presented increased risks for developing multi-drug resistant TB, with the OR (95% CI) of 11.07(1.45-84.50).
conclusionsThe present study demonstrated that Beijing family isolates were the most prevalent strains circulating in Jiangsu province of China. The utility of spoligotyping in combination with 24-loci MIRU-VNTR might be a useful tool for epidemiological analysis of MTB transmission.
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