GuidelineJournal of addictive diseases2011
QT interval screening in methadone maintenance treatment: report of a SAMHSA expert panel.
Guideline in Journal of addictive diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 6 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Methadone for critically ill patients under mechanical ventilation in the intensive care unit: a systematic review.Critical care science · 2025Pooled it
- Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2B6 Genotype and Methadone Therapy.Clinical pharmacology and therapeutics · 2024Guideline
- 2017 HIVMA of IDSA Clinical Practice Guideline for the Management of Chronic Pain in Patients Living With HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Guideline
- ACMT Position Statement: The Use of Methadone as an Analgesic.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2016Guideline
- Pain care for patients with epidermolysis bullosa: best care practice guidelines.BMC medicine · 2014Guideline
- QTc interval screening for cardiac risk in methadone treatment of opioid dependence.The Cochrane database of systematic reviews · 2013Pooled it
- Effectiveness of Conditioned Open-label Placebo With Methadone in Treatment of Opioid Use Disorder: A Randomized Clinical Trial.JAMA network open · 2023Trial
- Methadone administration and QT interval prolongation: protocol for a systematic review and meta-analysis.BMJ open · 2026Article
- Multimodal Analgesia in Cardiothoracic Procedure: Opioid and Non-opioid Pharmacology for Pain Management: Part 1.Annals of cardiac anaesthesia · 2025Review
- The effect of oral methadone on the QTc interval in cancer pain patients.Pain management · 2025Article
- Electrocardiographic Abnormalities During and After Withdrawal in Patients Diagnosed with Opioid Use Disorder.Noro psikiyatri arsivi · 2023Article
- Effects of Taijiquan and Qigong exercises on depression and anxiety levels in patients with substance use disorders: A systematic review and meta-analysis.Sports medicine and health science · 2022Review
- Effect of Methadone on Cardiac Repolarization in Japanese Cancer Patients: A Longitudinal Study.Cardiology and therapy · 2020Article
- Article
- A literature-based algorithm for the assessment, management, and monitoring of drug-induced QTc prolongation in the psychiatric population.Neuropsychiatric disease and treatment · 2019Review
- Sleep-Associated Torsades de Pointes: A Case Report.Clinical practice and cases in emergency medicine · 2017Article
- Caring for patients with opioid use disorder in the hospital.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016Review
- Warnings Unheeded:The Risks of Co-Prescribing Opioids and Benzodiazepines.Pain clinical updates · 2015Article
- Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration.Addiction (Abingdon, England) · 2015Article
- Medications for addiction treatment: an opportunity for prescribing clinicians to facilitate remission from alcohol and opioid use disorders.Rhode Island medical journal (2013) · 2014Review
Corrections and comments
- Erratum issuedHaigney, Mark C P [added]
Authors and funding
14 authors at 9 institutions in 1 country.
Funding
Abstract
In an effort to enhance patient safety in opioid treatment programs, the Substance Abuse and Mental Health Saervices Administration convened a multi-disciplinary Expert Panel on the Cardiac Effects of Methadone. Panel members (Appendix A) reviewed the literature, regulatory actions, professional guidances, and opioid treatment program experiences regarding adverse cardiac events associated with methadone. The Panel concluded that, to the extent possible, every opioid treatment program should have a universal Cardiac Risk Management Plan (incorporating clinical assessment, electrocardiogram assessment, risk stratification, and prevention of drug interactions) for all patients and should strongly consider patient-specific risk minimization strategies (such as careful patient monitoring, obtaining electrocardiograms as indicated by a particular patient's risk profile, and adjusting the methadone dose as needed) for patients with identified risk factors for adverse cardiac events. The Panel also suggested specific modifications to informed consent documents, patient education, staff education, and methadone protocols.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.