ArticleBMC genomics2011
Comparative genomic analysis of Streptococcus suis reveals significant genomic diversity among different serotypes.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51 citing papers in PubMed.
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- Comparative Genomics Analysis of the Fish Pathogen Rahnella aquatilis KCL-5 Reveals Potential Multidrug Resistance and Virulence Properties.Current microbiology · 2025Article
- Characterization Studies on theVeterinary sciences · 2024Article
- Promising potential of machine learning-assisted MALDI-TOF MS as an effective detector forApplied and environmental microbiology · 2023Article
- InvasiveFrontiers in cellular and infection microbiology · 2023Article
- Novel virulence factor Cba induces antibody-dependent enhancement (ADE) ofFrontiers in cellular and infection microbiology · 2023Article
- Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2Microbial genomics · 2022Article
- Comparative analysis of Streptococcus suis genomes identifies novel candidate virulence-associated genes in North American isolates.Veterinary research · 2022Article
- Acquiring high expression of suilysin enable non-epidemicEmerging microbes & infections · 2021Article
- Proposed virulence-associated genes of Streptococcus suis isolates from the United States serve as predictors of pathogenicity.Porcine health management · 2021Article
- Phenotype and multi-omics comparison of Staphylococcus and Streptococcus uncovers pathogenic traits and predicts zoonotic potential.BMC genomics · 2021Article
- Horizontal Transfer of DifferentFrontiers in microbiology · 2021Article
- Comparative Genomics, from the Annotated Genome to Valuable Biological Information: A Case Study.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Comparative Virulence and Genomic Analysis ofFrontiers in microbiology · 2020Article
- Article
- The Impact of SsPI-1 Deletion onPathogens (Basel, Switzerland) · 2019Article
- Bacitracin resistance and enhanced virulence of Streptococcus suis via a novel efflux pump.BMC veterinary research · 2019Article
- Micro-evolution of three Streptococcus species: selection, antigenic variation, and horizontal gene inflow.BMC evolutionary biology · 2019Article
- Pan- and core- gene association networks: Integrative approaches to understanding biological regulation.PloS one · 2019Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundStreptococcus suis (S. suis) is a major swine pathogen and an emerging zoonotic agent. Serotypes 1, 2, 3, 7, 9, 14 and 1/2 are the most prevalent serotypes of this pathogen. However, almost all studies were carried out on serotype 2 strains. Therefore, characterization of genomic features of other serotypes will be required to better understand their virulence potential and phylogenetic relationships among different serotypes.
resultsFour Chinese S. suis strains belonging to serotypes 1, 7, 9 and 1/2 were sequenced using a rapid, high-throughput approach. Based on the 13 corresponding serotype strains, including 9 previously completed genomes of this bacterium, a full comparative genomic analysis was performed. The results provide evidence that (i) the pan-genome of this species is open and the size increases with addition of new sequenced genomes, (ii) strains of serotypes 1, 3, 7 and 9 are phylogenetically distinct from serotype 2 strains, but all serotype 2 strains, plus the serotype 1/2 and 14 strains, are very closely related. (iii) all these strains, except for the serotype 1 strain, could harbor a recombinant site for a pathogenic island (89 K) mediated by conjugal transfer, and may have the ability to gain the 89 K sequence.
conclusionsThere is significant genomic diversity among different strains in S. suis, and the gain and loss of large amount of genes are involved in shaping their genomes. This is indicated by (i) pairwise gene content comparisons between every pair of these strains, (ii) the open pan-genome of this species, (iii) the observed indels, invertions and rearrangements in the collinearity analysis. Phylogenetic relationships may be associated with serotype, as serotype 2 strains are closely related and distinct from other serotypes like 1, 3, 7 and 9, but more strains need to be sequenced to confirm this.
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