ArticleBiomedical optics express2011
Detecting high-grade squamous intraepithelial lesions in the cervix with quantitative spectroscopy and per-patient normalization.
Article in Biomedical optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Model-based quantitative optical biopsy in multilayerJournal of medical imaging (Bellingham, Wash.) · 2018Article
- Development of thin skin mimicking bilayer solid tissue phantoms for optical spectroscopic studies.Biomedical optics express · 2017Article
- Detection of cervical lesions by multivariate analysis of diffuse reflectance spectra: a clinical study.Lasers in medical science · 2016Article
- The use of optical spectroscopy for in vivo detection of cervical pre-cancer.Lasers in medical science · 2014Review
- Early detection of high-grade squamous intraepithelial lesions in the cervix with quantitative spectroscopic imaging.Journal of biomedical optics · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
This study develops a spectroscopic algorithm for detection of cervical high grade squamous intraepithelial lesions (HSILs). We collected reflectance and fluorescence spectra with the quantitative spectroscopy probe to measure nine spectroscopic parameters from 43 patients undergoing standard colposcopy with directed biopsy. We found that there is improved accuracy for distinguishing HSIL from non-HSIL (low grade SIL and normal tissue) when we "normalized" spectroscopy parameters by dividing the values extracted from each clinically determined suspicious site by the corresponding value extracted from a clinically normal squamous site from the same patient. The "normalized" scattering parameter (A) at 700nm, best distinguished HSIL from non-HSIL with sensitivity and specificity of 89% and 79% suggesting that a simple, monochromatic instrument measuring only A may accurately detect HSIL.
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Registered trials
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