Evidence map›Paper›PMID 22025989›Full record

ArticleBiomedical optics express2011

Design and validation of a multiplexed low coherence interferometry instrument for in vivo clinical measurement of microbicide gel thickness distribution.

Tyler K Drake, Michael G Desoto, Jennifer J Peters, Marcus H Henderson, Amy P Murtha, David F Katz, Adam Wax

Abstract read
In one paragraph

Article in Biomedical optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tyler K Drake
Michael G Desoto
Jennifer J Peters
Marcus H Henderson
Amy P Murtha
David F Katz
Adam Wax

Funding

Preclinical User Accptability Studies Long Acting Vaginal Gels, Intravaginal RingU19AI077289 · NIAID · IMQUEST BIOSCIENCES · PI BUCKHEIT, ROBERT WALTER · 2008 to 2012
$6.7M
Assessing Deployment of Microbicidal Gels With Label-Free Optical MeasurementR21AI071816 · NIAID · DUKE UNIVERSITY · PI WAX, ADAM · 2007 to 2008
$419k
NIAID NIH HHS R21 AI071816NIAID NIH HHS U19 AI077289
6 · The paper itself

Abstract

We present a multiplexed, Fourier-domain low coherence interferometry (mLCI) instrument for in vivo measurement of intravaginal microbicide gel coating thickness distribution over the surface of the vaginal epithelium. The mLCI instrument uses multiple delivery fibers to acquire depth resolved reflection profiles across large scanned tissue areas. Here mLCI has been adapted into an endoscopic system with a custom imaging module for simultaneous, co-registered measurements with fluorimetric scans of the same surface. The resolution, optical signal-to-noise, and cross-talk of the mLCI instrument are characterized to evaluate performance. Validation measurements of gel thickness are made using a calibration socket. Initial results from a clinical study are presented to show the in vivo capability of the dual-modality system for assessing the distribution of microbicide gel vehicles in the lower human female reproductive tract.

Indexed as

(120.3180) Interferometry(120.3890) Medical optics instrumentation(170.4500) Optical coherence tomography

Identifiers

PMID22025989
PMCPMC3191450

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.