ArticleBiomedical optics express2011
Raman spectroscopy: a real-time tool for identifying microcalcifications during stereotactic breast core needle biopsies.
Article in Biomedical optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Diagnostic power of diffuse reflectance spectroscopy for targeted detection of breast lesions with microcalcifications.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer.Analytical methods : advancing methods and applications · 2023Article
- Raman spectroscopy: current applications in breast cancer diagnosis, challenges and future prospects.British journal of cancer · 2022Review
- Breast microcalcifications: Past, present and future (Review).Molecular and clinical oncology · 2022Review
- Review
- A New Look into Cancer-A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance.Cancers · 2021Review
- Quantitative chemical imaging of breast calcifications in association with neoplastic processes.Theranostics · 2020Article
- Optical Imaging Approaches to Investigating Radiation Resistance.Frontiers in oncology · 2019Review
- Applications of Raman spectroscopy in cancer diagnosis.Cancer metastasis reviews · 2018Review
- Label-Free Raman Imaging to Monitor Breast Tumor Signatures.Technology in cancer research & treatment · 2017Article
- Clinical instrumentation and applications of Raman spectroscopy.Chemical Society reviews · 2016Review
- Relationships between pathology and crystal structure in breast calcifications: anNPJ breast cancer · 2016Article
- Raman spectroscopic sensing of carbonate intercalation in breast microcalcifications at stereotactic biopsy.Scientific reports · 2015Article
- Photoacoustic imaging of breast microcalcifications: a preliminary study with 8-gauge core-biopsied breast specimens.PloS one · 2014Article
- Raman spectroscopy provides a powerful, rapid diagnostic tool for the detection of tuberculous meningitis in ex vivo cerebrospinal fluid samples.Journal of biophotonics · 2013Article
- Application of Raman spectroscopy to identify microcalcifications and underlying breast lesions at stereotactic core needle biopsy.Cancer research · 2013Article
- Raman imaging at biological interfaces: applications in breast cancer diagnosis.Molecular cancer · 2013Article
- Development and comparative assessment of Raman spectroscopic classification algorithms for lesion discrimination in stereotactic breast biopsies with microcalcifications.Journal of biophotonics · 2013Article
- Investigation of noise-induced instabilities in quantitative biological spectroscopy and its implications for noninvasive glucose monitoring.Analytical chemistry · 2012Article
- Precision of Raman spectroscopy measurements in detection of microcalcifications in breast needle biopsies.Analytical chemistry · 2012Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Microcalcifications are an early mammographic sign of breast cancer and a target for stereotactic breast needle biopsy. We present here a Raman spectroscopic tool for detecting microcalcifications in breast tissue based on their chemical composition. We collected ex vivo Raman spectra from 159 tissue sites in fresh stereotactic breast needle biopsies from 33 patients, including 54 normal sites, 75 lesions with microcalcifications and 30 lesions without microcalcifications. Application of our Raman technique resulted in a positive predictive value of 97% for detecting microcalcifications. This study shows that Raman spectroscopy has the potential to detect microcalcifications during stereotactic breast core biopsies and provide real-time feedback to radiologists, thus reducing non-diagnostic and false negative biopsies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.