ArticleBiomedical optics express2011
Born approximation model for light scattering by red blood cells.
Article in Biomedical optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Assessment of internal refractive index profile of stochastically inhomogeneous nuclear models via analysis of two-dimensional optical scattering patterns.Journal of biomedical optics · 2021Article
- Ocular anterior chamber blood cell population differentiation using spectroscopic optical coherence tomography.Biomedical optics express · 2019Article
- Dual-wavelength oblique back-illumination microscopy for the non-invasive imaging and quantification of blood in collection and storage bags.Biomedical optics express · 2018Article
- Classification of biological micro-objects using optical coherence tomography: in silico study.Biomedical optics express · 2017Article
- Theoretical model for optical oximetry at the capillary level: exploring hemoglobin oxygen saturation through backscattering of single red blood cells.Journal of biomedical optics · 2017Article
- Article
- Reflectance confocal microscopy of red blood cells: simulation and experiment.Biomedical optics express · 2015Article
- Subdiffusion reflectance spectroscopy to measure tissue ultrastructure and microvasculature: model and inverse algorithm.Journal of biomedical optics · 2015Article
- Label-free characterization of emerging human neuronal networks.Scientific reports · 2014Article
- Opposed-view dark-field digital holographic microscopy.Biomedical optics express · 2014Article
- Advances in optics for biotechnology, medicine and surgery.Biomedical optics express · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The primary role of a red blood cell (RBC) is delivering oxygen throughout our body. Abnormalities of this basic function lead to anemia and are caused by numerous diseases such as malaria and sickle cell anemia. As prompt and inexpensive tests for blood screening are in demand, we have developed a faster and reliable way to measure morphological parameters associated with the structure of red blood cells and the size distribution of the cells in a whole blood smear. Modeling the RBC shape under Born approximation, we are able to determine parameters of clinical relevance, such as the diameter, thickness and dimple size. From a measured quantitative phase image of a blood smear, we can determine the average and standard deviation of the red blood cell volume simultaneously, i.e., without analyzing each cell individually. This approach may open the door for a new generation of label-free, high-throughput blood testing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.