ArticleProceedings of the National Academy of Sciences of the United States of America2011
Noninvasive MRI of β-cell function using a Zn2+-responsive contrast agent.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
78 citing papers in PubMed.
- Molecular Imaging of In Vivo Zinc Distribution Using Nuclear and Magnetic Resonance Imaging.Chemical & biomedical imaging · 2026Review
- Deuterated Molecular Probes for Metal Sensing.ACS omega · 2026Article
- Molecular MRI of Dysregulated Zinc Secretion Detects Pancreatic Ductal Adenocarcinoma and Response to KRASG12D Inhibitor Treatment.Cancer research · 2025Article
- The role of responsive MRI probes in the past and the future of molecular imaging.Chemical science · 2024Review
- A Reactive and Specific Sensor for Activity-BasedACS sensors · 2024Article
- Impact of dietary zinc on stimulated zinc secretion MRI in the healthy and malignant mouse prostate.Npj imaging · 2024Article
- Imaging in Type 1 Diabetes, Current Perspectives and Directions.Molecular imaging and biology · 2023Article
- Polymer-Based Nanostructures for Pancreatic Beta-Cell Imaging and Non-Invasive Treatment of Diabetes.Pharmaceutics · 2023Review
- Rational design of a genetically encoded NMR zinc sensor.Chemical science · 2023Article
- MRI Methods for Imaging Beta-Cell Function in the Rodent Pancreas.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Impact of anFrontiers in endocrinology · 2023Article
- Imaging evaluation of the pancreas in diabetic patients.Abdominal radiology (New York) · 2022Review
- Molecular fMRI of neurochemical signaling.Journal of neuroscience methods · 2021Review
- Inside the Insulin Secretory Granule.Metabolites · 2021Review
- Fast Ion-Chelate Dissociation Rate forJournal of the American Chemical Society · 2021Article
- Towards Photoswitchable Contrast Agents for Absolute 3D Temperature MR Imaging.Angewandte Chemie (International ed. in English) · 2021Article
- Highly Potent MRI Contrast Agent Displaying Outstanding Sensitivity to Zinc Ions.Angewandte Chemie (International ed. in English) · 2021Article
- Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI.Inorganic chemistry · 2021Article
- Imaging Beta-Cell Function in the Pancreas of Non-Human Primates Using a Zinc-Sensitive MRI Contrast Agent.Frontiers in endocrinology · 2021Article
- Imaging β-Cell Function Using a Zinc-Responsive MRI Contrast Agent May Identify First Responder Islets.Frontiers in endocrinology · 2021Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Elevation of postprandial glucose stimulates release of insulin from granules stored in pancreatic islet β-cells. We demonstrate here that divalent zinc ions coreleased with insulin from β-cells in response to high glucose are readily detected by MRI using the Zn(2+)-responsive T(1) agent, GdDOTA-diBPEN. Image contrast was significantly enhanced in the mouse pancreas after injection of a bolus of glucose followed by a low dose of the Zn(2+) sensor. Images of the pancreas were not enhanced by the agent in mice without addition of glucose to stimulate insulin release, nor were images enhanced in streptozotocin-treated mice with or without added glucose. These observations are consistent with MRI detection of Zn(2+) released from β-cells only during glucose-stimulated insulin secretion. Images of mice fed a high-fat (60%) diet over a 12-wk period and subjected to this same imaging protocol showed a larger volume of contrast-enhanced pancreatic tissue, consistent with the expansion of pancreatic β-cell mass during fat accumulation and progression to type 2 diabetes. This MRI sensor offers the exciting potential for deep-tissue monitoring of β-cell function in vivo during development of type 2 diabetes or after implantation of islets in type I diabetic patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.