ArticleThe Journal of physiology2011
Antagonism of the TRPv1 receptor partially corrects muscle metaboreflex overactivity in spontaneously hypertensive rats.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 66 citations in OpenAlex.
- TRPV1 deletion in male mice alters cardiomyocyte ultrastructure without affecting baseline cardiac function.Scientific reports · 2025Article
- High Dietary Phosphate Intake Induces Hypertension and Sympathetic Overactivation via Central Fibroblast Growth Factor Receptor Signaling.Circulation · 2025Article
- Blunted pressor response to peripheral sensory afferent nerve stimulation in intracerebroventricular-streptozotocin injected rats.Autonomic neuroscience : basic & clinical · 2025Article
- Does hypertension exacerbate the age-related exaggerated pressor response to dynamic exercise during post-exercise muscle ischemia?Physiological reports · 2025Article
- Abnormal cardiovascular control during exercise: Role of insulin resistance in the brain.Autonomic neuroscience : basic & clinical · 2025Review
- Altered Autonomic Function in Metabolic Syndrome: Interactive Effects of Multiple Components.Journal of clinical medicine · 2024Review
- What are the cardiovascular responses during blood flow-restricted resistance exercise?Frontiers in physiology · 2024Article
- Functional knockout of the TRPV1 channel has no effect on the exercise pressor reflex in rats.The Journal of physiology · 2023Article
- Sex-dependent attenuating effects of capsaicin administration on the mechanoreflex in healthy rats.American journal of physiology. Heart and circulatory physiology · 2023Article
- Dapagliflozin Attenuates Sympathetic and Pressor Responses to Stress in Young Prehypertensive Spontaneously Hypertensive Rats.Hypertension (Dallas, Tex. : 1979) · 2022Article
- The exercise pressor reflex: An update.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Review
- Gene and protein expression of dorsal root ganglion sensory receptors in normotensive and hypertensive male rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Insulin potentiates the response to capsaicin in dorsal root ganglion neurons in vitro and muscle afferents ex vivo in normal healthy rodents.The Journal of physiology · 2022Article
- Purinergic signaling as a new mechanism underlying physical exercise benefits: a narrative review.Purinergic signalling · 2021Review
- Muscle metaboreflex adaptations to exercise training in health and disease.European journal of applied physiology · 2021Review
- Chronic ablation of TRPV1-sensitive skeletal muscle afferents attenuates the muscle metaboreflex.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- TRPV1 (Transient Receptor Potential Vanilloid 1) Sensitization of Skeletal Muscle Afferents in Type 2 Diabetic Rats With Hyperglycemia.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Recent advances in exercise pressor reflex function in health and disease.Autonomic neuroscience : basic & clinical · 2020Review
- Insulin resistance is associated with an exaggerated blood pressure response to ischemic rhythmic handgrip exercise in nondiabetic older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Skeletal Muscle Reflex-Induced Sympathetic Dysregulation and Sensitization of Muscle Afferents in Type 1 Diabetic Rats.Hypertension (Dallas, Tex. : 1979) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The circulatory response to exercise is exaggerated in hypertension potentially increasing the risk for adverse cardiovascular events. Evidence suggests the skeletal muscle metaboreflex contributes to this abnormal circulatory response. However, as the sensitivity of this reflex has been reported to be both reduced and potentiated in hypertension, its role remains controversial. In addition, the receptor mechanisms underlying muscle metaboreflex dysfunction in this disease remain undetermined. To address these issues, metaboreflex activity was assessed during 'supra-stimulation' of the reflex via ischaemic hindlimb muscle contraction. This manoeuvre evoked significantly larger increases in mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA) in spontaneously hypertensive rats (SHR) compared to normotensive Wistar-Kyoto (WKY) rats. The skeletal muscle TRPv1 receptor was evaluated as a potential mediator of this metaboreflex response as it has been shown to contribute significantly to muscle reflex activation in healthy animals. Stimulation of the TRPv1 receptor by injection of capsaicin into the arterial supply of the hindlimb evoked significantly larger elevations in MAP and RSNA in SHR compared to WKY. The pressor and sympathetic responses to ischaemic muscle contraction in WKY and SHR were attenuated by the administration of the TRPv1 receptor antagonist capsazepine with the magnitude of the capsazepine-induced reductions being greater in SHR than WKY. TRPv1 protein expression in dorsal root ganglia, but not skeletal muscle, was significantly greater in SHR than WKY. The results suggest the muscle metaboreflex is overactive in hypertension. Further, this reflex overactivity can be partially normalized by antagonizing TRPv1 receptors in skeletal muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.