ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Cutting edge: Natural helper cells derive from lymphoid progenitors.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
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Who cites it
80 citing papers in PubMed, 144 citations in OpenAlex.
- The IL-33-ILC2 axis: a key regulator of type 2 immunity in respiratory disease.Frontiers in immunology · 2026Review
- ILC2 Diversity, Location, and Function in Pulmonary Disease.Immunological reviews · 2025Review
- RAG suppresses group 2 innate lymphoid cells.eLife · 2025Article
- Mef2d potentiates type-2 immune responses and allergic lung inflammation.Science (New York, N.Y.) · 2024Article
- Review
- Parallel origins and functions of T cells and ILCs.Clinical and experimental immunology · 2023Review
- Crosstalk between the gut microbiota and innate lymphoid cells in intestinal mucosal immunity.Frontiers in immunology · 2023Review
- Trickle infection withFrontiers in immunology · 2022Article
- ILC Differentiation from Progenitors in the Bone Marrow.Advances in experimental medicine and biology · 2022Review
- Group 2 innate lymphoid cells are numerically and functionally deficient in the triple transgenic mouse model of Alzheimer's disease.Journal of neuroinflammation · 2021Article
- Localization and site-specific cell-cell interactions of group 2 innate lymphoid cells.International immunology · 2021Review
- Non-atopic Neonatal Thymic Innate Lymphoid Cell Subsets (ILC1, ILC2, and ILC3) Identification and the Modulatory Effect of IgG From Dermatophagoides Pteronyssinus (Derp)-Atopic Individuals.Frontiers in allergy · 2021Article
- Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity.Frontiers in immunology · 2021Article
- The role of innate lymphoid cells in selected disease states - cancer formation, metabolic disorder and inflammation.Archives of medical science : AMS · 2021Article
- Abortive γδTCR rearrangements suggest ILC2s are derived from T-cell precursors.Blood advances · 2020Article
- A novel bispecific antibody targeting CD3 and prolactin receptor (PRLR) against PRLR-expression breast cancer.Journal of experimental & clinical cancer research : CR · 2020Article
- Activation of group 2 innate lymphoid cells alleviates aging-associated cognitive decline.The Journal of experimental medicine · 2020Article
- Compartmentalized effects of aging on group 2 innate lymphoid cell development and function.Aging cell · 2019Article
- Shared Transcriptional Control of Innate Lymphoid Cell and Dendritic Cell Development.Annual review of cell and developmental biology · 2019Review
- γδTCR-independent origin of neonatal γδ T cells prewired for IL-17 production.Current opinion in immunology · 2019Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Natural helper (NH) cells are recently discovered innate immune cells that confer protective type 2 immunity during helminth infection and mediate influenza-induced airway hypersensitivity. Little is known about the ontogeny of NH cells. We report in this study that NH cells derive from bone marrow lymphoid progenitors. Using RAG-1Cre/ROSA26(YFP) mice, we show that most NH cells are marked with a history of RAG-1 expression, implying lymphoid developmental origin. The development of NH cells depends on the cytokine receptor Flt3, which is required for the efficient generation of bone marrow lymphoid progenitors. Finally, we demonstrate that lymphoid progenitors, but not myeloid-erythroid progenitors, give rise to NH cells in vivo. This work therefore expands the lymphocyte family, currently comprising T, B, and NK cells, to include NH cells as another type of innate lymphocyte that derives from bone marrow lymphoid progenitors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.