ArticleInfection and immunity2012
Differential role of the interleukin-17 axis and neutrophils in resolution of inhalational anthrax.
Article in Infection and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- The role of ixekizumab in the treatment of nonradiographic axial spondyloarthritis.Immunotherapy · 2024Review
- Review
- IL-17 Production of Neutrophils Enhances Antibacteria Ability but Promotes Arthritis Development During Mycobacterium tuberculosis Infection.EBioMedicine · 2017Article
- TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.The Journal of experimental medicine · 2017Article
- Chemokine-Releasing Microparticles Improve Bacterial Clearance and Survival of Anthrax Spore-Challenged Mice.PloS one · 2016Article
- Correlation of Surface Toll-Like Receptor 9 Expression with IL-17 Production in Neutrophils during Septic Peritonitis in Mice Induced by E. coli.Mediators of inflammation · 2016Article
- Potential role of autophagy in the bactericidal activity of human PMNs for Bacillus anthracis.Pathogens and disease · 2015Article
- Cytokine crowdsourcing: multicellular production of TH17-associated cytokines.Journal of leukocyte biology · 2015Review
- Role reversal: infiltrating T cells protect the brain.The Journal of clinical investigation · 2015Article
- Natural cutaneous anthrax infection, but not vaccination, induces a CD4(+) T cell response involving diverse cytokines.Cell & bioscience · 2015Article
- Adult non-cystic fibrosis bronchiectasis is characterised by airway luminal Th17 pathway activation.PloS one · 2015Article
- Reverse-Phase Microarray Analysis Reveals Novel Targets in Lymph Nodes of Bacillus anthracis Spore-Challenged Mice.PloS one · 2015Article
- Crossing of the epithelial barriers by Bacillus anthracis: the Known and the Unknown.Frontiers in microbiology · 2015Review
- Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Aspergillus and Fusarium corneal infections are regulated by Th17 cells and IL-17-producing neutrophils.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The IL-23/Th17 axis is involved in the adaptive immune response to Bacillus anthracis in humans.European journal of immunology · 2014Article
- Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2.Nature immunology · 2014Article
- Two-photon intravital imaging of lungs during anthrax infection reveals long-lasting macrophage-dendritic cell contacts.Infection and immunity · 2014Article
- Immunity to infection in IL-17-deficient mice and humans.European journal of immunology · 2012Review
- Both lethal and edema toxins of Bacillus anthracis disrupt the human dendritic cell chemokine network.PloS one · 2012Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The roles of interleukin-17 (IL-17) and neutrophils in the lung have been described as those of two intricate but independent players. Here we identify neutrophils as the primary IL-17-secreting subset of cells in a model of inhalation anthrax using A/J and C57BL/6 mice. With IL-17 receptor A knockout (IL-17RA-/-) mice, we confirmed that IL-17A/F signaling is instrumental in the self-recruitment of this population. We also show that the IL-17A/F axis is critical for surviving pulmonary infection, as IL-17RA-/- mice become susceptible to intranasal infection by Bacillus anthracis Sterne spores. Strikingly, infection with a fully virulent strain did not affect IL-17RA-/- mouse survival. Eventually, by depleting neutrophils in wild-type and IL-17RA-/- mice, we demonstrated the crucial role of IL-17-secreting neutrophils in mouse survival of infection by fully virulent B. anthracis. This work demonstrates the important roles of both IL-17 signaling and neutrophils in clearing this pathogen and surviving pulmonary B. anthracis infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.