ArticleHypertension (Dallas, Tex. : 1979)2011
Genetic variants and blood pressure in a population-based cohort: the Cardiovascular Risk in Young Finns study.
Article in Hypertension (Dallas, Tex. : 1979), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents.Circulation. Cardiovascular genetics · 2016Pooled it
- Genetic Susceptibility, Dietary Protein Intake, and Changes of Blood Pressure: The POUNDS Lost Trial.Hypertension (Dallas, Tex. : 1979) · 2019Trial
- Body mass index modifies genetic susceptibility to high systolic blood pressure in adolescents and young adults: results from an 18-year longitudinal study.Journal of human hypertension · 2025Article
- Pediatric Blood Pressure and Cardiovascular Health in Adulthood.Current hypertension reports · 2024Review
- Exome sequencing implicates ancestry-related Mendelian variation at SYNE1 in childhood-onset essential hypertension.JCI insight · 2024Article
- Genetic Variants Associated With Systolic Blood Pressure in Children and Adolescents.Journal of the American Heart Association · 2023Article
- Development of a genetic risk score to predict the risk of hypertension in European adolescents from the HELENA study.Frontiers in cardiovascular medicine · 2023Article
- Article
- Identifying the predictive effectiveness of a genetic risk score for incident hypertension using machine learning methods among populations in rural China.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Sex Differences in Genetic Risk for Hypertension.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Genetic Risk Scores for Complex Disease Traits in Youth.Circulation. Genomic and precision medicine · 2020Article
- Assessing genetic risk of hypertension at an early age: future research directions.Expert review of cardiovascular therapy · 2017Article
- Prediction of Adulthood Obesity Using Genetic and Childhood Clinical Risk Factors in the Cardiovascular Risk in Young Finns Study.Circulation. Cardiovascular genetics · 2017Article
- Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents.Neuroscience and biobehavioral reviews · 2017Review
- Parental and offspring contribution of genetic markers of adult blood pressure in early life: The FAMILY study.PloS one · 2017Article
- Genetic Programming of Hypertension.Frontiers in pediatrics · 2017Review
- Prediction of Blood Pressure and Blood Pressure Change With a Genetic Risk Score.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Pediatric Blood Pressure and Adult Preclinical Markers of Cardiovascular Disease.Clinical medicine insights. Blood disorders · 2016Review
- Familial aggregation and childhood blood pressure.Current hypertension reports · 2015Review
- The Role of Genetic Risk Score in Predicting the Risk of Hypertension in the Korean population: Korean Genome and Epidemiology Study.PloS one · 2015Article
Corrections and comments
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Authors and funding
23 authors at 1 institution in 1 country.
Funding
Abstract
Clinical relevance of a genetic predisposition to elevated blood pressure was quantified during the transition from childhood to adulthood in a population-based Finnish cohort (N=2357). Blood pressure was measured at baseline in 1980 (age 3-18 years) and in follow-ups in 1983, 1986, 2001, and 2007. Thirteen single nucleotide polymorphisms associated with blood pressure were genotyped, and 3 genetic risk scores associated with systolic and diastolic blood pressures and their combination were derived for all of the participants. Effects of the genetic risk score were 0.47 mm Hg for systolic and 0.53 mm Hg for diastolic blood pressures (both P<0.01). The combination genetic risk score was associated with diastolic blood pressure from age 9 years onward (β=0.68 mm Hg; P=0.015). Replications in 1194 participants of the Bogalusa Heart Study showed essentially similar results. The participants in the highest quintile of the combination genetic risk score had a 1.82-fold risk of hypertension in adulthood (P<0.0001) compared with the lowest quintile, independent of a family history of premature hypertension. These findings show that genetic variants are associated with preclinical blood pressure traits in childhood; individuals with several susceptibility alleles have, on average, a 0.5-mm Hg higher blood pressure, and this trajectory continues from childhood to adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.