ReviewContrast media & molecular imaging
Advanced contrast nanoagents for photoacoustic molecular imaging, cytometry, blood test and photothermal theranostics.
Review in Contrast media & molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 117 citations in OpenAlex.
- Dual-modality ultrasound/photoacoustic tomography for mapping tissue oxygen saturation distribution in intestinal strangulation.Photoacoustics · 2025Article
- The utilization of nanotechnology in the female reproductive system and related disorders.Heliyon · 2024Review
- Molecular and cellular imaging of the eye.Biomedical optics express · 2024Review
- Nanomaterial-Based Scaffolds for Tissue Engineering Applications: A Review on Graphene, Carbon Nanotubes and Nanocellulose.Tissue engineering and regenerative medicine · 2023Review
- The sound of blood: photoacoustic imaging in blood analysis.Medicine in novel technology and devices · 2023Article
- Recent Progress on Molecular Photoacoustic Imaging with Carbon-Based Nanocomposites.Materials (Basel, Switzerland) · 2021Review
- Seeing through the Skin: Photoacoustic Tomography of Skin Vasculature and Beyond.JID innovations : skin science from molecules to population health · 2021Review
- Active matter therapeutics.Nano today · 2020Article
- Photoacoustic and fluorescent effects in multilayer plasmon-dye interfaces.Journal of biophotonics · 2019Article
- Bioinspired magnetic nanoparticles as multimodal photoacoustic, photothermal and photomechanical contrast agents.Scientific reports · 2019Article
- Smart nanomedicine agents for cancer, triggered by pH, glutathione, HInternational journal of nanomedicine · 2019Review
- Recent progress in photoacoustic molecular imaging.Current opinion in chemical biology · 2018Review
- Current status, pitfalls and future directions in the diagnosis and therapy of lymphatic malformation.Journal of biophotonics · 2018Review
- Recent Advances of Activatable Molecular Probes Based on Semiconducting Polymer Nanoparticles in Sensing and Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2017Review
- A practical guide to photoacoustic tomography in the life sciences.Nature methods · 2016Review
- Fluorescent ampicillin analogues as multifunctional disguising agents against opsonization.Nanoscale · 2016Article
- Long circulating reduced graphene oxide-iron oxide nanoparticles for efficient tumor targeting and multimodality imaging.Nanoscale · 2016Article
- High-resolution contrast-enhanced optical coherence tomography in mice retinae.Journal of biomedical optics · 2016Article
- Bond-selective photoacoustic imaging by converting molecular vibration into acoustic waves.Photoacoustics · 2016Review
- Multiscale photoacoustic tomography using reversibly switchable bacterial phytochrome as a near-infrared photochromic probe.Nature methods · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Various nanoparticles have raised significant interest over the past decades for their unique physical and optical properties and biological utilities. Here we summarize the vast applications of advanced nanoparticles with a focus on carbon nanotube (CNT)-based or CNT-catalyzed contrast agents for photoacoustic (PA) imaging, cytometry and theranostics applications based on the photothermal (PT) effect. We briefly review the safety and potential toxicity of the PA/PT contrast nanoagents, while showing how the physical properties as well as multiple biological coatings change their toxicity profiles and contrasts. We provide general guidelines needed for the validation of a new molecular imaging agent in living subjects, and exemplify these guidelines with single-walled CNTs targeted to α(v) β(3) , an integrin associated with tumor angiogenesis, and golden carbon nanotubes targeted to LYVE-1, endothelial lymphatic receptors. An extensive review of the potential applications of advanced contrast agents is provided, including imaging of static targets such as tumor angiogenesis receptors, in vivo cytometry of dynamic targets such as circulating tumor cells and nanoparticles in blood, lymph, bones and plants, methods to enhance the PA and PT effects with transient and stationary bubble conjugates, PT/PA Raman imaging and multispectral histology. Finally, theranostic applications are reviewed, including the nanophotothermolysis of individual tumor cells and bacteria with clustered nanoparticles, nanothrombolysis of blood clots, detection and purging metastasis in sentinel lymph nodes, spectral hole burning and multiplex therapy with ultrasharp rainbow nanoparticles.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.