ArticleThe Journal of experimental medicine2011
In situ induction of dendritic cell-based T cell tolerance in humanized mice and nonhuman primates.
Article in The Journal of experimental medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- The role of islet autoantigen-specific T cells in the onset and treatment of type 1 diabetes mellitus.Frontiers in immunology · 2024Review
- Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- Dendritic Cells: Versatile Players in Renal Transplantation.Frontiers in immunology · 2021Review
- CD4Xenotransplantation · 2020Article
- Tolerogenic dendritic cells in organ transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2020Review
- Functional Human CD141+ Dendritic Cells in Human Immune System Mice.The Journal of infectious diseases · 2020Article
- Distinct Roles of LFA-1 and ICAM-1 on ILC2s Control Lung Infiltration, Effector Functions, and Development of Airway Hyperreactivity.Frontiers in immunology · 2020Article
- CD4Journal of immunology research · 2018Article
- Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement.Transplantation · 2016Article
- Application of Humanized Mice in Immunological Research.Methods in molecular biology (Clifton, N.J.) · 2016Review
- Tolerogenic dendritic cells and their applications in transplantation.Cellular & molecular immunology · 2015Review
- Orchestration of transplantation tolerance by regulatory dendritic cell therapy or in-situ targeting of dendritic cells.Current opinion in organ transplantation · 2014Review
- A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease.Mucosal immunology · 2013Article
- Human hemato-lymphoid system mice: current use and future potential for medicine.Annual review of immunology · 2013Review
- Induction of donor-specific tolerance: is this achievable?The Korean journal of internal medicine · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
21 authors at 7 institutions in 4 countries.
Funding
Abstract
Induction of antigen-specific T cell tolerance would aid treatment of diverse immunological disorders and help prevent allograft rejection and graft versus host disease. In this study, we establish a method of inducing antigen-specific T cell tolerance in situ in diabetic humanized mice and Rhesus monkeys receiving porcine islet xenografts. Antigen-specific T cell tolerance is induced by administration of an antibody ligating a particular epitope on ICAM-1 (intercellular adhesion molecule 1). Antibody-mediated ligation of ICAM-1 on dendritic cells (DCs) led to the arrest of DCs in a semimature stage in vitro and in vivo. Ablation of DCs from mice completely abrogated anti-ICAM-1-induced antigen-specific T cell tolerance. T cell responses to unrelated antigens remained unaffected. In situ induction of DC-mediated T cell tolerance using this method may represent a potent therapeutic tool for preventing graft rejection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.