ArticleThe Journal of pathology2012
Immunophenotypic and genomic characterization of papillary carcinomas of the breast.
Article in The Journal of pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 101 citations in OpenAlex.
- Intraductal papillary carcinoma of breast with invasion: A nomogram and survival from the analysis of the SEER database.Cancer medicine · 2023Trial
- Case Report: Genomic profiling in an invasive solid papillary carcinoma patient with liver metastasis and a history of invasive lobular carcinoma.Pathology oncology research : POR · 2025Article
- Invasive papillary carcinoma of the breast: A case report.Oncology letters · 2024Article
- Invasive papillary carcinoma of the breast.Frontiers in oncology · 2024Review
- Uncommon invasive lobular carcinoma with papillary architecture-clinicopathologic and molecular characterization with review of the literature.Virchows Archiv : an international journal of pathology · 2023Review
- Intraductal papilloma with atypical ductal hyperplasia and neuroendocrine differentiation as a possible precursor lesion of solid papillary carcinoma.Medical molecular morphology · 2023Article
- Papillary lesions of the breast.Virchows Archiv : an international journal of pathology · 2022Review
- Breast carcinomas of low malignant potential.Virchows Archiv : an international journal of pathology · 2022Review
- Solid papillary carcinoma of the breast.Autopsy & case reports · 2022Review
- Molecular analysis of TCGA breast cancer histologic types.Cell genomics · 2021Article
- Papillary neoplasms of the breast-reviewing the spectrum.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Review
- Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Review
- Breast cancer organoids from a patient with giant papillary carcinoma as a high-fidelity model.Cancer cell international · 2020Article
- Exploring Collagen Parameters in Pure Special Types of Invasive Breast Cancer.Scientific reports · 2019Article
- A pilot evaluation of magnetic resonance imaging characteristics seen with solid papillary carcinomas of the breast in 4 patients.BMC cancer · 2017Article
- Subclonal analysis in a lobular breast cancer with classical and solid growth pattern mimicking a solid-papillary carcinoma.The journal of pathology. Clinical research · 2017Article
- Natural History of Invasive Papillary Breast Carcinoma Followed for 10 Years: A Case Report and Literature Review.Case reports in medicine · 2017Article
- Intracystic papillary carcinoma of the breast: A SEER database analysis of implications for therapy.Breast (Edinburgh, Scotland) · 2016Article
- In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer.Nature genetics · 2015Article
- Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification.Genome biology · 2015Article
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 2 countries.
Funding
Abstract
Papillary carcinomas are a special histological type of breast cancer and have a relatively good outcome. We characterized the genomic and phenotypic characteristics of papillary carcinomas to determine whether they would constitute an entity distinct from grade- and oestrogen receptor (ER)-matched invasive ductal carcinomas of no special type (IDC-NSTs). The phenotype of 63 papillary carcinomas of the breast and grade- and ER-matched IDC-NSTs was determined by immunohistochemistry. DNA of sufficient quality was extracted from 49 microdissected papillary carcinomas and 49 microdissected grade- and ER-matched IDC-NSTs. These samples were subjected to high-resolution microarray-based comparative genomic hybridization (aCGH) and Sequenom MassARRAY sequencing analysis of 19 known oncogenes. Papillary carcinomas were predominantly of low histological grade, expressed immunohistochemical markers consistent with a luminal phenotype, and a lower rate of lymph node metastasis and p53 expression than grade- and ER-matched IDC-NSTs. Papillary carcinomas displayed less genomic aberrations than grade- and ER-matched IDC-NSTs; however, the patterns of gene copy number aberrations found in papillary carcinomas were similar to those of ER- and grade-matched IDC-NSTs, including 16q losses. Furthermore, PIK3CA mutations were found in 43% and 29% of papillary carcinomas and grade- and ER-matched IDC-NSTs, respectively. The genomic profiles of encapsulated, solid and invasive papillary carcinomas, the three morphological subtypes, were remarkably similar. Our results demonstrate that papillary carcinomas are a homogeneous special histological type of breast cancer. The similarities in the genomic profiles of papillary carcinomas and grade- and ER-matched IDC-NSTs suggest that papillary carcinomas may be best positioned as part of the spectrum of ER-positive breast cancers, rather than as a distinct entity. Furthermore, the good prognosis of papillary carcinomas may stem from the low rates of lymph node metastasis and p53 expression, low number of gene copy number aberrations and high prevalence of PIK3CA mutations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.