ArticleCells, tissues, organs2012
Right ventricular outflow tract repair with a cardiac biologic scaffold.
Article in Cells, tissues, organs, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- AnMaterials today. Communications · 2023Article
- Characterization of Bioinks Prepared via Gelifying Extracellular Matrix from Decellularized Porcine Myocardia.Gels (Basel, Switzerland) · 2023Article
- Progress in the application of patch materials in cardiovascular surgery.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Functional acellular matrix for tissue repair.Materials today. Bio · 2023Review
- Stabilizing A Vascularized Autologous Matrix with Flexible Magnesium Scaffolds to Reconstruct Dysfunctional Left Ventricular Myocardium in a Large-Animal Feasibility Study.Journal of functional biomaterials · 2023Article
- Whole-Heart Tissue Engineering and Cardiac Patches: Challenges and Promises.Bioengineering (Basel, Switzerland) · 2023Review
- Right Ventricular Outflow Tract Surgical Resection in Young, Large Animal Model for the Study of Alternative Cardiovascular Patches.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Bidirectional relationship between cardiac extracellular matrix and cardiac cells in ischemic heart disease.Stem cells (Dayton, Ohio) · 2021Review
- The Real Need for Regenerative Medicine in the Future of Congenital Heart Disease Treatment.Biomedicines · 2021Review
- Xenogeneic and Stem Cell-Based Therapy for Cardiovascular Diseases: Genetic Engineering of Porcine Cells and Their Applications in Heart Regeneration.International journal of molecular sciences · 2020Review
- Bearing My Heart: The Role of Extracellular Matrix on Cardiac Development, Homeostasis, and Injury Response.Frontiers in cell and developmental biology · 2020Review
- Young at Heart: Combining Strategies to Rejuvenate Endogenous Mechanisms of Cardiac Repair.Frontiers in bioengineering and biotechnology · 2020Review
- Cardiac tissue-derived extracellular matrix scaffolds for myocardial repair: advantages and challenges.Regenerative biomaterials · 2019Review
- Decellularized neonatal cardiac extracellular matrix prevents widespread ventricular remodeling in adult mammals after myocardial infarction.Acta biomaterialia · 2019Article
- Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration.Advanced healthcare materials · 2019Review
- A novel human-derived tissue-engineered patch for vascular reconstruction.American journal of translational research · 2019Article
- Patch materials for right ventricular outflow reconstruction: past, present, and future.Indian journal of thoracic and cardiovascular surgery · 2019Review
- Use of an Extracellular Matrix Patch for Sternal Wound Dehiscence after Cardiac Surgery in a Neonate.Texas Heart Institute journal · 2018Article
- Article
- Is Decellularized Porcine Small Intestine Sub-mucosa Patch Suitable for Aortic Arch Repair?Frontiers in pediatrics · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundSurgical reconstruction of congenital heart defects is often limited by the nonresorbable material used to approximate normal anatomy. In contrast, biologic scaffold materials composed of resorbable non-cross-linked extracellular matrix (ECM) have been used for tissue reconstruction of multiple organs and are replaced by host tissue. Preparation of whole organ ECM by decellularization through vascular perfusion can maintain much of the native three-dimensional (3D) structure, strength, and tissue-specific composition. A 3D cardiac ECM (C-ECM) biologic scaffold material would logically have structural and functional advantages over materials such as Dacron™ for myocardial repair, but the in vivo remodeling characteristics of C-ECM have not been investigated to date. METHODS AND
resultsA porcine C-ECM patch or Dacron patch was used to reconstruct a full-thickness right ventricular outflow tract (RVOT) defect in a rat model with end points of structural remodeling function at 16 weeks. The Dacron patch was encapsulated by dense fibrous tissue and showed little cellular infiltration. Echocardiographic analysis showed that the right ventricle of the hearts patched with Dacron were dilated at 16 weeks compared to presurgery baseline values. The C-ECM patch remodeled into dense, cellular connective tissue with scattered small islands of cardiomyocytes. The hearts patched with C-ECM showed no difference in the size or function of the ventricles as compared to baseline values at both 4 and 16 weeks.
conclusionsThe C-ECM patch was associated with better functional and histomorphological outcomes compared to the Dacron patch in this rat model of RVOT reconstruction.
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