Evidence map›Paper›PMID 22025056›Full record

ReviewNature reviews. Immunology2011

Studying the mononuclear phagocyte system in the molecular age.

Andrew Chow, Brian D Brown, Miriam Merad

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 161 papers.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04052048 recruitingnot on this mapstarted 2019, after this paper: background citation

A Multi-center, Prospective Active Surveillance Registry Trial Assessing the Performance of a Non-invasive Immunogenomic Blood Test for Indolent Prostate Cancer Disease Management.

Typeobservational_patient_registrySponsorImmunis.AIRan2019 to 2029Enrolled2,000ConditionsProstate Cancer AggressivenessArmsSubtraction Normalized Expression of Phagocytes Blood Test
NCT05370300 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Subtraction Normalized Aggregated Phagocytic Signal in Peripheral Blood of Breast Cancer Patients (SNAPS - Clinical Trial) A NextGen RNASeq Feasibility Study of a Blood-based Model for Early Cancer Detection and Surveillance

TypeobservationalSponsorImmunis.AIRan2025 to 2027Enrolled500ConditionsBreast Cancer, Breast Cancer FemaleArmsBlood test
3 · Its place in the literature

Who cites it

161 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. The role of DAP12 in immune-related inflammatory diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Decades Long Involvement of THP-1 Cells as a Model for Macrophage Research: A Comprehensive Review.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. BAP31 Knockout in Macrophages Affects CD4International journal of molecular sciences · 2023
    Article
  20. CD4Nature immunology · 2023
    Article

101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrew ChowDepartment of Oncological Sciences and Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.
Brian D Brown
Miriam Merad

Funding

Ontogeny of Gut Dendritic Cells in Steady State and Inflamed SettingsR01HL086899 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MERAD, MIRIAM · 2007 to 2011
$2.1M
Homeostasis of dendritic cells and GVHDR01CA112100 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MERAD, MIRIAM · 2006 to 2010
$1.5M
Dissecting the origin and the function of the cutaneous dendritic cell networkR01AI080884 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MERAD, MIRIAM · 2009 to 2010
$950k
COMPARATIVE STUDY OF COAGULATION &VASCULAR DISEASER01HL009902 · NHLBI · WADSWORTH CENTER · PI DODDS, WINIFRED J · 1985 to 1993
–
NCI NIH HHS CA112100NHLBI NIH HHS 5F30HL099028‑02NHLBI NIH HHS HL086899NIAID NIH HHS 1R56AI081741‑01A1NIAID NIH HHS AI080884NIDDK NIH HHS DP2DK083052‑01
6 · The paper itself

Abstract

The mononuclear phagocyte system (MPS) comprises monocytes, macrophages and dendritic cells. Tissue phagocytes share several cell surface markers, phagocytic capability and myeloid classification; however, the factors that regulate the differentiation, homeostasis and function of macrophages and dendritic cells remain largely unknown. The purpose of this manuscript is to review the tools that are currently available and those that are under development to study the origin and function of mononuclear phagocytes.

Indexed as

AnimalsCell DifferentiationDendritic CellsGene Expression ProfilingHumansMacrophagesMonocytesProteomicsRNA InterferenceSequence Analysis, DNA

Identifiers

PMID22025056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.