ArticleNature chemistry2011
A sequence-specific threading tetra-intercalator with an extremely slow dissociation rate constant.
Article in Nature chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- High-affinity A/T-rich DNA binding with a dimeric bisbenzamidine.NAR molecular medicine · 2024Article
- Fluorescent Dynamic Covalent Polymers for DNA Complexation and Templated Assembly.Molecules (Basel, Switzerland) · 2022Article
- Heat-shrinking DNA nanoparticles for in vivo gene delivery.Gene therapy · 2020Article
- From Interaction to Function in DNA-Templated Supramolecular Self-Assemblies.ChemistryOpen · 2020Review
- Diazapyrenes: interaction with nucleic acids and biological activity.Chemistry of heterocyclic compounds · 2020Article
- Ethyl-substitutive Thioflavin T as a highly-specific fluorescence probe for detecting G-quadruplex structure.Scientific reports · 2018Article
- Single molecule high-throughput footprinting of small and large DNA ligands.Nature communications · 2017Article
- Design, Synthesis and Evaluation of Bifunctional Acridinine-Naphthalenediimide Redox-Active Conjugates as Antimalarials.ACS omega · 2016Article
- Exploiting the interactions of aromatic units for folding and assembly in aqueous environments.Chemical communications (Cambridge, England) · 2016Article
- Mechanisms of small molecule-DNA interactions probed by single-molecule force spectroscopy.Nucleic acids research · 2016Article
- Article
- Single-molecule kinetics and footprinting of DNA bis-intercalation: the paradigmatic case of Thiocoraline.Nucleic acids research · 2015Article
- Strong DNA deformation required for extremely slow DNA threading intercalation by a binuclear ruthenium complex.Nucleic acids research · 2014Article
- Molecular recognition of DNA by ligands: roughness and complexity of the free energy profile.The Journal of chemical physics · 2013Article
- Threading polyintercalators with extremely slow dissociation rates and extended DNA binding sites.Journal of the American Chemical Society · 2013Article
- Single-molecule study of the CUG repeat-MBNL1 interaction and its inhibition by small molecules.Nucleic acids research · 2013Article
- Molecular assembly of amino acid interlinked, topologically symmetric, π-complementary donor-acceptor-donor triads.Beilstein journal of organic chemistry · 2013Article
- Subtle recognition of 14-base pair DNA sequences via threading polyintercalation.Biochemistry · 2012Article
- Designed compounds for recognition of 10 base pairs of DNA with two at binding sites.Journal of the American Chemical Society · 2012Article
- DNA complexes: Durable binders.Nature chemistry · 2011Article
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5 authors.
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Abstract
A long-lived and sequence-specific ligand-DNA complex would make possible the modulation of biological processes for extended periods. For this purpose, we are investigating a polyintercalation approach to DNA recognition in which flexible chains of aromatic units thread back and forth repeatedly through the double helix. Here we describe the DNA-binding behaviour of a threading tetra-intercalator. Specific binding was observed on a relatively long DNA strand that strongly favoured a predicted 14 base-pair sequence. Kinetic studies revealed a multistep association process, with sequence specificity that primarily derives from large differences in dissociation rates. The rate-limiting dissociation rate constant of the tetra-intercalator complex dissociating from its preferred binding site was extremely slow, corresponding to a half-life of 16 days. This is one of the longest non-covalent complex half-lives yet reported and, to the best of our knowledge, the longest for a DNA-binding molecule.
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