Evidence map›Paper›PMID 22024829›Full record

ArticleAntimicrobial agents and chemotherapy2012

Antifungal susceptibilities of Aspergillus fumigatus clinical isolates obtained in Nagasaki, Japan.

Masato Tashiro, Koichi Izumikawa, Asuka Minematsu, Katsuji Hirano, Naoki Iwanaga, Shotaro Ide, Tomo Mihara, Naoki Hosogaya, Takahiro Takazono, Yoshitomo Morinaga and 12 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Non-viableMicrobiology spectrum · 2026
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  8. Uncovering a NovelJournal of fungi (Basel, Switzerland) · 2024
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  9. Microbiology spectrum · 2023
    Article
  10. Characterization of Aspergillus spp. isolated from patients with coronavirus disease 2019.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2023
    Article
  11. Review
  12. Article
  13. Osseous Infections Caused byDiagnostics (Basel, Switzerland) · 2022
    Review
  14. Native Joint Infections byDiagnostics (Basel, Switzerland) · 2021
    Review
  15. Prognostic Scores and Azole-ResistantJournal of fungi (Basel, Switzerland) · 2021
    Article
  16. Fungal Septic Knee Arthritis Caused byDiagnostics (Basel, Switzerland) · 2021
    Article
  17. Spondylodiscitis Caused byDiagnostics (Basel, Switzerland) · 2021
    Review
  18. Article
  19. A Cyp51B Mutation Contributes to Azole Resistance inJournal of fungi (Basel, Switzerland) · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Masato TashiroDepartment of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Koichi Izumikawa
Asuka Minematsu
Katsuji Hirano
Naoki Iwanaga
Shotaro Ide
Tomo Mihara
Naoki Hosogaya
Takahiro Takazono
Yoshitomo Morinaga
Shigeki Nakamura
Shintaro Kurihara
Yoshifumi Imamura
Taiga Miyazaki
Tomoya Nishino
Misuzu Tsukamoto
Hiroshi Kakeya
Yoshihiro Yamamoto
Katsunori Yanagihara
Akira Yasuoka
Takayoshi Tashiro
Shigeru Kohno

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the triazole, amphotericin B, and micafungin susceptibilities of 196 A. fumigatus clinical isolates in Nagasaki, Japan. The percentages of non-wild-type (non-WT) isolates for which MICs of itraconazole, posaconazole, and voriconazole were above the ECV were 7.1%, 2.6%, and 4.1%, respectively. A G54 mutation in cyp51A was detected in 64.2% (9/14 isolates) and 100% (5/5 isolates) of non-WT isolates for itraconazole and posaconazole, respectively. Amphotericin B MICs of ≥2 μg/ml and micafungin minimum effective concentrations (MECs) of ≥16 μg/ml were recorded for two and one isolates, respectively.

Indexed as

Amino Acid SubstitutionAmphotericin BAntifungal AgentsAspergillosisAspergillus fumigatusCytochrome P-450 Enzyme SystemDrug Resistance, FungalEchinocandinsFemaleFungal ProteinsHumansItraconazoleJapanLipopeptidesMaleMicafunginAmphotericin BAntifungal Agentscytochrome P-450 CYP51A, AspergillusCytochrome P-450 Enzyme SystemEchinocandinsFungal ProteinsItraconazoleLipopeptidesMicafunginposaconazolePyrimidinesTriazolesVoriconazole

Identifiers

PMID22024829
PMCPMC3256053

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.